摘要
阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome,OSAS)是一种临床上的常见病,而OSAS所致认知障碍中神经递质的变化是可能的致病机制,神经递质作用于相应的受体发挥保护或者损伤作用,通过激活相关信号通路、抑制或加重细胞凋亡、介导脑内的炎性介质反应及调节突触可塑性,从而影响认知功能。
Obstructive sleep apnea Syndrome is a common disease in clinic.The change of neurotransmitters in cognitive disorders caused by OSAS is a possible pathogenic mechanism.Neurotransmitters act on corresponding receptors to produce protection or damage.They affect cognitive function by activating related signal pathways,inhibiting or aggravating cell death,mediating inflammatory mediator response in brain and regulating synaptic plasticity.
作者
黄琴
刘海军
徐平
Huang Qin;Liu Haijun;Xu ping(Department of Neurology,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China)
出处
《遵义医科大学学报》
2020年第2期254-258,共5页
Journal of Zunyi Medical University
基金
国家自然科学基金资助项目(NO:81660194)。
