摘要
[目的]探讨布地奈德雾化吸入治疗早产儿支气管肺发育不良(BPD)的疗效.[方法]回顾性分析92例本院诊治的BPD的早产儿临床资料,按照治疗方法分为布地奈德组29例、地塞米松组34例、对照组29例(未使用糖皮质激素).[结果]治疗后,与对照组相比,布地奈德组和地塞米松组的BPD分度较轻;但布地奈德组和地塞米松组比较差异无统计学意义(P>0.05).对照组的输氧时间、使用无创机械通气时间均显著高于地塞米松组和布地奈德组,其差异具有统计学意义(P<0.05);但三组住院时间、出院后氧疗比较差异均无统计学意义(P>0.05).三组脓毒血症、动脉导管未闭(HsPDA)、脑室内出血(IVH)≥Ⅲ级、脑白质软化(PVL)、坏死性小肠结肠炎(NEC)、消化道出血、肺动脉高压(PPHN)、高血糖发生率比较差异均无统计学意义(P>0.05).[结论]对于需持续用氧或使用呼吸机的早产儿,早期(≥14 d)使用布地奈德雾化吸入对其BPD有治疗的作用,可减少患儿用氧时间和机械通气时间,避免患儿全身使用糖皮质激素,且未见近期不良并发症,但远期预后仍需进一步研究.
[Objective]To investigate the effect of Budesonide aerosol inhalation in the treatment of bronchop‐ulmonary dysplasia(BPD)in premature infants.[Methods]The clinical data of 92 cases of BPD in our hospital were analyzed retrospectively.According to the treatment methods,they were divided into 29 cases of budesonide group,34 cases of dexamethasone group and 29 cases of control group(without glucocorticoid).[Results]After treatment,BPD scores of the budesonide group and the dexamethasone group were lighter than those of the control group,but there was no significant difference between the budesonide group and the dexamethasone group(P>00.5).Compared with the dexamethasone group and the budesonide group,the time of oxygen delivery and the time of noninvasive mechanical ventilation in the control group were significantly longer(P<0.05),but there was no significant difference in the time of hospitalization and oxygen therapy after discharge in the three groups(P>00.5).There was no significant difference in the incidence of sepsis,patent ductus arteriosus(HsPDA),in‐traventricular hemorrhage(IVH)≥gradeⅢ,PVL,necrotizing enterocolitis(NEC),gastrointestinal hemor‐rhage,pulmonary hypertension(PPHN)and hyperglycemia among the three groups(P>00.5)[.Conclusion]For premature infants who need continuous oxygen use or ventilator use,early(≥14 days)use of budesonide atomi‐zation inhalation has therapeutic effect on their BPD,which can reduce the time of oxygen use and mechanical ven‐tilation,avoid the use of glucocorticoids in the whole body,and no short‐term adverse complications are found,but the long‐term prognosis still needs further study.
作者
黎江
陈铁强
吴敏
张路
周耀
齐华雪
LI Jiang;CHEN Tie-qiang;WU Min(Neonatal Department,Chan gsha Maternal and Healtheare Haspial,Changsha Hunan 40000)
出处
《医学临床研究》
CAS
2020年第5期652-654,共3页
Journal of Clinical Research
基金
湖南省卫生计生委科研计划课题项目(编号:B2017228)。
