摘要
目的探讨儿童糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)严重程度的危险因素及其防治对策。方法回顾性分析安徽省儿童医院2016年1月至2020年1月收治的69例DKA患儿的临床资料,按照DKA严重程度,将入选患儿分别纳入轻度组(32例)和中/重度组(37例)。对比两组患儿临床资料和实验室检查结果,将组间对比差异有统计学意义的因素纳入多因素Logistic回归分析(计量资料以总均值或正常值为界值转化为二分类资料),分析影响儿童DKA严重程度的危险因素。结果多因素Logistic回归分析结果显示,年龄≤7岁、血尿素氮(blood urea nitrogen,BUN)≥8.50 mmol/L、血钠≤135 mmol/L、延误诊断均为影响儿童DKA严重程度的独立危险因素(均P<0.05)。结论导致儿童中/重度DKA发生发展的因素包括年龄≤7岁、延误诊断以及BUN、血钠水平变化,临床应重视对DKA高危患儿的识别,加强对BUN和血钠的干预。
Objective To analyze the risk factors affecting the severity of diabetic ketoacidosis(DKA)in children and to explore the prevention and treatment strategies.Method The clinical data of 69 children with DKA admitted in Anhui Provincial Children's Hospital from January 2016 to January 2020 were collected.According to the severity of DKA,the children were divided into mild group(32 cases)and moderate/severe group(37 cases).The clinical data and laboratory test results of the two groups were compared.The factors with statistical differences between the two groups were included in the multiple Logistic regression analysis(the measurement data were transformed into the binary data with the total mean or normal value as the boundary),and the relevant risk factors affecting the severity of DKA in children were analyzed.Result Multiple Logistic regression analysis showed that age≤7 years old,blood urea nitrogen(BUN)≥8.50 mmol/L,blood sodium≤135 mmol/L and delayed diagnosis were the independent risk factors for the severity of DKA in children(all P<0.05).Conclusion The factors leading to the occurrence and development of moderate/severe DKA in children include age≤7 years old,delayed diagnosis and the changes of BUN and blood sodium.Clinical attention should be paid to the identification of high-risk children with DKA,and the intervention of BUN and blood sodium should be strengthened.
作者
王娟娟
高健
邓茜
王忻
陈雨青
Wang Juanjuan;Gao Jian;Deng Qian;Wang Xin;Chen Yuqing(Department of Endocrinology and Rheumatology,Anhui Provincial Children's Hospital,Hefei 230051,China)
出处
《中国医学前沿杂志（电子版）》
2020年第6期107-110,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
安徽医科大学校科研基金(2019xkj080)。
