摘要
电化学生物传感器是基于传感器表面抗体和抗原相互作用的生物传感器,将抗体(抗原)固定在传感器表面后再分别用来检测抗原(抗体)。相比其他生物传感器,电化学传感器具有较好的选择性和较高的灵敏度,因此在不同的科学领域具有广泛的应用前景。本文综述了电化学生物传感器的工作原理、分类、抗原抗体的固定方法,以及在食品安全、临床医学和环境监测领域的应用,并进一步指出目前生物传感器存在的不足之处以及今后研究的重点方向。
Electrochemical biosensor is a biosensor based on the interaction of antibody and antigen on the surface of the sensor.The antibody(antigen)is fixed on the surface of the sensor and then used to detect the antigen(antibody)respectively.Compared with other biosensors,electrochemical sensors have better selectivity and higher sensitivity,so they have wide application prospects in different scientific fields.In this paper,the working principle,classification,immobilization of antigen and antibody,and the application in food safety,clinical medicine and environmental monitoring are reviewed.The shortcomings of biosensor and the future research directions are pointed out.
作者
王彬
曾冬冬
徐晓慧
李晖
莫艳红
WANG Bin;ZENG Dongdong;XU Xiaohui;LI Hui;MO Yanhong(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093;Shanghai University of Medicine & Health Sciences,Shanghai 201318)
出处
《北京生物医学工程》
2020年第3期311-316,326,共7页
Beijing Biomedical Engineering
基金
国家自然科学基金青年科学基金(21605152)
上海市自然科学基金(19ZR1474300)资助。
关键词
电化学生物传感器
食品安全
临床医学
环境监测
electrochemical biosensor
food safety
clinical medicine
environmental monitoring
