摘要
目的:探究血浆D-二聚体(D-Dimer,DD)和纤维蛋白原(Fibrinogen,Fg)对结直肠癌患者手术后生存状况的预测效果。方法:选取2017年1月至2018年12月接受治疗的82例结直肠癌患者为研究对象,按照D-D水平和不同Fg水平将患者分组,其中D-D<0.5 g·kg^-1组共47例,D-D≥0.5 g·kg^-1组共35例,Fg<4 g·L^-1组共44例,Fg≥4 g·L^-1组共38例,采用QOL-C30量表评估患者的生活质量水平,同时观察记录术后1年内结直肠癌复发率以及患者术后1年的生存率。结果:D-D<0.5 g·kg^-1组QOL-C30量表评分和复发率均明显低于D-D≥0.5 g·kg^-1组(P<0.05),而生存率显著高于D-D≥0.5 g·kg^-1组(P<0.05)。Fg<4 g·L^-1组QOL-C30量表评分和复发率低于Fg≥4 g·L^-1组(P<0.05),生存率则高于Fg≥4 g·L^-1组(P<0.05)。COX回归分析显示,D-D≥0.5 g·kg^-1,Fg≥4 g·L^-1是结直肠癌患者术后1年生存率低的危险因素。结论:血浆DD和Fg与结直肠癌患者的术后生活质量、复发率以及死亡率相关。
Objective:To investigate the predictive effects of plasma D-dimers(D-D)and fibrinogen(Fg)on the survival of colorectal cancer patients after surgery.Methods:Eight-two patients with colorectal cancer treated in our hospital from January 2017 to December 2018 were randomly divided into D-D<0.5 mg·L^-1 group(n=47),D-D≥0.5 mg·L^-1 group(n=35),Fg<4 g·L^-1group(n=44),and Fg≥4 g·L^-1 group(n=38).Recurrence rate within 1 year after surgery and survival rate within 1 year after surgery were recorded.Results:Compared with D-D≥0.5 g·kg^-1,the QOL-C30 scale score and recurrence rate in the D-D<0.5 g·L^-1 group were lower,and the survival rate was higher(P<0.05).Compared with Fg≥4 g·L^-1,the score and recurrence rate of QOL-C30 in Fg<4 g·L^-1 group were lower,and the survival rate was higher(P<0.05).COX regression analysis showed that D-D≥0.5 g·L^-1and Fg≥4 g·L^-1 were risk factors for low one-year survival rate in patients with colorectal cancer.Conclusion:Plasma DD and Fg levels are related to the postoperative quality of life,recurrence rate and mortality of patients with colorectal cancer.
作者
姜巧丽
樊浩然
赵东亮
Jiang Qiao-li;Fan Hao-ran;Zhao Dong-liang(Laboratory Medical Center,Zhengzhou Yihe Hospital,Zhengzhou 450000,China;Department of Rehabilitation Medicine,Zhengzhou Yihe Hospital,Zhengzhou 450000,China;Department of Hematology,Pingdingshan First People's Hospital,Pingdingshan 467000,Henan,China)
出处
《四川生理科学杂志》
2020年第2期147-150,共4页
Sichuan Journal of Physiological Sciences
