摘要
针对感染乙型肝炎(乙肝)病毒(HBV)的孕妇,临床采用干扰素,免疫球蛋白和抗病毒药物达到控制病毒量,切断母婴传播的手段。其中干扰素由于病毒应答率低且禁用于孕妇,需停药半年才能妊娠。单用乙肝免疫球蛋白和乙肝疫苗虽然能有效阻断大部分垂直传播,但对于部分乙肝病毒高载量孕妇,依然存在阻断失败,其原因主要是病毒的宫内感染。近期,越来越多的研究报道核苷酸类似物药物替比夫定,替诺福韦在病毒高载量孕妇中的使用可以有效的降低乙肝病毒载量,阻断病毒垂直传播,且具有一定的安全性。但有关产后停药及哺乳相关随访需要更多医学证据。
For pregnant women infected with Hepatitis B virus(HBV),interferon,immunoglobulin and antiviral drugs are clinically used to control viral load and the transmission from mother-to-child.The viral response rate is low for interferon,and the use is prohibited in pregnant women,6 months of drug free period is required before getting pregnant.Although Hepatitis B immunoglobulin and Hepatitis B vaccine alone can effectively block most vertical transmission,for some pregnant women with high Hepatitis B virus load,treatment failure still exists,mainly because of intrauterine infection.Recently,increasing number of studies reported that the use of tibivudine and tenofovir,a nucleotide analogue drug,can effectively reduce Hepatitis B viral load in pregnant women with high viral load and block the vertical transmission of the virus,and is relatively safe.However,more medical evidence is needed for post-natal discontinuation,and breast-feeding related follow ups.
作者
陈铂
李江
廖露琴
徐创
CHEN Bo;LI Jiang;LIAO Lu-qin(Guilin Medical University Affiliated Hospital,Guilin 541001,China)
出处
《中国现代药物应用》
2020年第11期232-234,共3页
Chinese Journal of Modern Drug Application
基金
桂医科【2018】5号中青年教职工科研能力提升项目(项目编号:2018glmcy059)。
关键词
乙型肝炎
妊娠
替比夫定
替诺福韦
母婴传播
Hepatitis B
Pregnancy
Telbivudine
Tenofovir
Mother-to-child transmission
