摘要
脑出血是神经内科常见的急危重症,发病后形成初级损伤和继发性损伤,造成严重的神经功能缺损和脑损伤。为了应对这种损伤,大脑启动了如小胶质细胞极化及细胞自噬活动等自我修复机制,旨在通过抑制损伤、促进修复以维持中枢神经系统内环境的稳态。然而这种内源性修复具有一定的局限。因此,外源性干预以促进机体抑制损伤、促进修复显得尤为重要。近年来,中医药治疗脑出血因其多靶点、多途径、多环节作用特点,得到广泛关注。探讨脑出血后中医药干预发挥的促进机体抑制损伤、促进修复双重作用机制,有助于进一步阐明和提高中医药治疗脑出血的临床疗效。
Intracerebral hemorrhage(ICH)is a commonly acute and critical disease in neurology department.Primary injury and secondary injury can be formed after it occurs,causing severely neurologic deficits and brain damage.In defense to the injury,the brain activate repair mechanisms like polarization of microglial and autophagy,which aims to maintain internal environment homeostasis of central nervous system by inhibiting injury and promoting repair.However,the endogenous repair has certain limitations.It is particularly important to motivate the function of inhibiting injury and promoting repair by exogenous intervention.In recent years,Chinese medicine treatment of ICH draws widely attention due to their characteristics of multi-target,multi-channel and multi-link.To explore the dual mechanism of TCM intervention after ICH,which can motivate the function of inhibiting injury and promoting repair,is helpful to further clarify and improve the clinical efficacy of TCM in the treatment of ICH.
作者
江珊
俞晓飞
Jiang Shan;Yu Xiaofei(Department of Neurology of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第2期346-352,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
上海市科学技术委员会中医重点项目(19401972800):生地大黄汤治疗火热迫血型急性出血性卒中随机、对照、双盲、多中心临床疗效评价,负责人:俞晓飞
国家自然科学基金委员会青年科学基金课题(81503555):生地大黄汤通过HMGB1/TLR4/MMP-9信号通路保护急性脑出血时血脑屏障的机制研究,负责人:俞晓飞
国家中管局全国中医药创新骨干人才培训项目,国中医药人教函〔2019〕128号,负责人:俞晓飞。
关键词
中医药
脑出血
小胶质细胞
细胞自噬
损伤-修复
Intracerebral hemorrhage
Traditional Chinese medicine
Microglial
Autophagy
Injury-repair
