摘要
湖北武汉爆发新冠肺炎(COVID-19)疫情,给我国公共卫生事业带来了巨大挑战。新型冠状病毒(SARS-CoV-2)结合血管紧张素转化酶2(ACE2)受体激活经典的肾素-血管紧张素系统(RAS)调节途径,作用于肺及肺外靶器官,引发多脏器损伤。中医药干预COVID-19,临床疗效可观,且多种中药能够调控RAS。本文通过阐述RAS在SARS-CoV-2所致多脏器损伤中的作用以及中药对其干预调控作用,旨在为后续临床相关研究及治疗、抗新冠病毒药物研发提供指导依据。
Public health management in our country is greatly challenged by the outbreak of coronavirus disease(COVID-19)in Wuhan(Hubei).SARS-CoV-2,by binding to angiotenisn-converting enzyme-2(ACE2),activates the classic renin-angiotensin system(RAS),which acts on lungs and non-lung targeting organs,consequently inducing injuries in multiple organs.Clinical therapeutic efficacy of traditional Chinese medicine(TCM)was demonstrated in COVID-19 patients since TCM could regulate RAS.This paper provides direction evidences for future relevant research and treatment in clinic and drug research and development for anti-SARS-CoV-2 through evaluating the effects of RAS in SARS-CoV-2-induced injuries in multiple organs and the intervention and regulatory effects of TCM on COVID-19.
作者
张岩
唐德志
舒冰
李文雄
张佳莉
李钺
赫明超
沙南南
施杞
王拥军
Zhang Yan;Tang Dezhi;Shu Bing;Li Wenxiong;Zhang Jiali;Li Yue;He Mingchao;Sha Nannan;Shi Qi;Wang Yongjun(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Spine Disease Research Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education,Shanghai 200032,China;Traumatological Academic Research Center of Shi Xiao Shan,Shanghai 200032,China;Famous Traditional Chinese Medicine Studio of Shi Qi,Shanghai 200032,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第2期264-269,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上项目(81774329)
国家自然科学基金重点项目(81730107)
国家重点研发计划项目(2018YFC1704300)
教育部创新团队发展计划项目(IRT1270)
科技部重点领域创新团队计划项目(2015RA4002)
上海市市级医疗卫生优秀学科带头人培养计划资助(2018BR03)
上海市优秀学术带头人计划资助(19XD1423800)
上海市科委自然科学基金(17ZR1430800)
上海市三年行动计划(ZY(2018-2020)-CCCX-3003)。
