摘要
目的以杞菊地黄丸为研究对象,采用时域反射法实时测定浓缩丸干燥过程中水分含量及对干燥工艺进行参数优化。方法通过水分、温度以及时域反射计反射信号值之间的关系建立杞菊地黄丸干燥过程水分模型;以马钱苷和丹皮酚的干燥前后转移率为评价指标,结合干燥总用时、杞菊地黄丸的外观形态,综合考察药丸不同厚度(8、16、24 mm)、不同干燥温度(30、40、50、60、70、80、90℃)对干燥工艺的影响并对变温参数进行分析、验证。结果采用时域反射法测试杞菊地黄丸干燥过程水分模型为Y=0.305 X-34.772,r^2=0.999;X=X(T)-(0.768 9 T-24.824 7)(T≥30℃);优化后工艺为以60℃干燥至水分为13.8%后升温到80℃后继续干燥至7.80%后降温至60℃干燥到目标水分5.0%。结论时域反射法实时测试杞菊地黄丸干燥过程中水分的含量是可行的,该方法可尝试在中药浓缩丸干燥过程中水分监测推广应用,而且该方法可应用于中药浓缩丸干燥工艺优化,使干燥过程变得节能省时,使干燥产品质量可控。
Objective Taking Qiju Dihuang Pills(QDP) as the research object, time domain reflection method was used for real-time determination of moisture content in concentrated pills during drying process and optimization of the drying process parameters. Methods The moisture model of the drying process of QDP was established by the relationship between the water, temperature, and the reflective signal value of time domain reflector. The effect of the drying process on the different thickness(8, 16, and 24 mm), different drying temperatures(30, 40, 50, 60, 70, 80, and 90 ℃) was investigated. Results The moisture model of the drying process of QDP was measured by time domain reflection method as Y = 0.305 X-34.772(r^2 = 0.999);X = X(T)-(0.768 9 T-24.824 7)(T ≥ 30 ℃). The optimized process was as following: the process was dried at 60 ℃ to 13.8% moisture and then rising to 80 ℃, after being dried to 7.80%, cooled to 60 ℃ and dried to 5.0% target moisture. Conclusion It is feasible to test the moisture content in the drying process of QDP by time domain reflection method. This method can be used to monitor and popularize the moisture content in the drying process of traditional Chinese medicine concentrated pills.
作者
侯晓雅
何芳辉
孙小梅
郑海涛
于采薇
李毅
王玉琦
刘伟婷
陈大全
HOU Xiao-ya;HE Fang-hui;SUN Xiao-mei;ZHENG Hai-tao;YU Cai-wei;LI Yi;WANG Yu-qi;LIU Wei-ting;CHEN Da-quan(School of Pharmacy,Yantai University,Yantai 264005,China;Xi’an Hele Biotechnology Co.,Ltd.,Xi’an 710075,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第10期2767-2772,共6页
Chinese Traditional and Herbal Drugs
基金
山东省“泰山学者青年专家”工程项目(qnts20161035)
山东省自然科学基金重大基础基金项目(ZR2019ZD24)
山东省优秀青年基金项目(ZR2019YQ30)。
关键词
时域反射法
杞菊地黄丸
在线水分测定
干燥工艺
变温干燥
马钱苷
丹皮酚
转移率
time domain reflection
Qiju Dihuang Pills
on-line moisture determination
drying optimization
variable temperature drying
loganin
paeonol
transport rate
