摘要
目的:探讨高频振荡通气(HFOV)联合多巴胺治疗新生儿持续性肺动脉高压(PPHN)的效果及对氧合指数(OI)、D-二聚体(D-D)水平的影响。方法:选取2018年2月~2019年2月某院收治的90例PPHN患儿为对象,按照随机数字法分为对照组(n=45)和观察组(n=45),对照组给予HFOV治疗,观察组给补高频振荡通气联合多多巴胺治疗,比较两组临床疗效,血氧饱和度(SpO2)、OI、血清C反应蛋白(CRP)、脑钠肽(BNP)、D-D水平的变化。结果:治疗后观察组总有效率为93.33%显著高于对照组的71.11%(P<0.05);治疗后观察组OI低于对照组,SpO2高于对照组(P<0.05);治疗后观察组血清CRP、BNP及D-D水平均显著低于对照组(P<0.05)。结论:HFOV联合多巴胺治疗PPHN的效果显著,能够改善机体缺氧状态,降低炎性因子。
Objective:To explore the effects of high frequency oscillatory ventilation(HFOV) combined with dopamine on persistent pulmonary hypertension of the newborn(PPHN)and its influence on oxygenation index(OI)and D-Dimer(D-D)level.Methods:A total of 90 children patients with PPHN admitted to a hospital from February 2018 to February 2019 were selected for the study and were divided into control group(n=45)and observation group(n=45)according to the random number table method.The control group was given HFOV,and the observation group was given high-frequency oscillatory ventilation combined with dopamine.The clinical efficacy,and levels of blood oxygen saturation(SpO2),OI,serum C-reactive protein(CRP),brain natriuretic peptide(BNP)and D-D were compared between the two groups.Results:After treatment,the total effective rate in observation group was significantly higher than that in control group(93.33% vs 71.11%)(P<0.05).After treatment,the OI in observation group was lower than that in control group while the SpO2 was higher than that in control group(P<0.05).The levels of serum CRP,BNP and D-D in observation group after treatment were significantly lower than those in control group(P<0.05).Conclusion:HFOV combined with dopamine has significant effects in the treatment of PPHN,and it can improve the anoxic conditions and reduce the inflammatory factors.
作者
蔡云
Cai Yun(Kaifeng Qi County Maternal and Child Care Service Centre,Kaifeng 475200)
出处
《数理医药学杂志》
2020年第6期857-859,共3页
Journal of Mathematical Medicine
