摘要
作为大脑固有免疫细胞,小胶质细胞在阿尔兹海默症(Alzheimer’s disease,AD)的发病过程中发挥着不可替代的作用。过去的研究一直使用传统M1、M2分型来解释小胶质细胞的功能,但随着技术的发展,我们现在可以从细胞转录组学或基因组学、蛋白组学等方面来更加全面地认识小胶质细胞,而不是仅仅靠几个标志基因来对小胶质细胞进行分型。疾病相关的小胶质细胞(disease associated microglia,DAM)就是从细胞转录组学的角度建立的小胶质细胞亚型,这一亚型的确立对于构建小胶质细胞新的分型意义重大,并且预测了许多新的AD危险位点,对于下一步研究至关重要。
Microglia,which are innate immune cells in the brain,play an irreplaceable role in the pathogenesis of Alzheimer’s disease.The M1/M2 model has previously been used to explain the function of microglia.However,advances in technology,especially in cell transcriptome genomics,i.e.,proteomics,have enabled a more comprehensive understanding of microglia.Disease-related microglia,one of the subtypes established from the perspective of the cell transcriptome,is of great significance for the construction of new subtypes of microglia.Indeed,this subtype may facilitate the prediction of many new AD risk sites in future research.
作者
崔雨沙
路欣
李峰
CUI Yusha;LU Xin;LI Feng(2016 Undergraduate,Major in five-year Clinical Medicine,School of Basic Medical Science,Capital Medical University,Beijing 100069,China;Morphological Laboratory of Experimental Teaching Center of Basic Medicine,School of Basic Medical Science,Capital Medical University,Beijing 100069;Neurobiology Department,Beijing Institute for Brain Disorders,Beijing Center of Neural Regeneration and Repair,Capital Medical University,Beijing 100069)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第5期132-136,共5页
Chinese Journal of Comparative Medicine
基金
首都医科大学学生科研创新项目资助(XSKY2019001)。
