摘要
目的对颅脑肿瘤患者进行生存曲线分析,探讨影响颅脑肿瘤患者预后的相关因素。方法回顾性分析郑州大学第一附属医院2012-04—2015-01治疗的140例颅脑肿瘤患者的临床资料,对患者进行电话、门诊、微信等方式随访,随访截止2020-01-01,获取患者的生存状态或死亡时间,主要观察终点是总生存期,应用Kaplan-Meier法计算生存率,通过Cox比例风险模型行多因素分析,探讨颅脑肿瘤患者预后的影响因素。结果随访结束时,1 a生存率为87.78%,3 a生存率为43.33%,5 a生存率为29.29%,中位生存时间(MST)为34.6个月。结合患者性别、年龄、病理类型、治疗方式等临床特征分析发现,年龄、手术方式、术前KPS评分、病理分型、有无术后放疗、有无术后化疗、Ki-67水平对患者术后预后有显著影响(P<0.05);而性别、肿瘤最大直径、有无钙化、有无脑积水对生存期无明显影响(P>0.05);COX比例风险回归分析显示,年龄、手术方式、术前KPS、病理分型、术后放疗、术后化疗、Ki-67水平是颅脑肿瘤患者预后的影响因素。结论年龄越大、术前KPS评分越低、Ki-67表达水平越高、病理类型为脑转移瘤患者预后越差,全切手术、术后进行放化疗将有助于改善患者预后。
Objective To analyze the survival curve of the patients with craniocerebral tumors,and related factors affecting the prognosis.Methods The clinical data of 140 patients with craniocerebral tumors in the hospital during the period from April 2012 to January 2015 were retrospectively analyzed.All were followed up by telephone,outpatient service and letters.The deadline of follow-up was January 1,2020.Their survival situations and death time were obtained.The main observation destination was the overall survival time.The survival rate was calculated by Kaplan-Meier method.The multivariate analysis was conducted by Cox proportional hazards model to determine the related influencing factors of survival in patients with craniocerebral tumors.Results The 1-year survival rate,3-year survival rate,5-year survival rate and median survival time(MST)were 87.78%,43.33%,29.29%and 34.6 months,respectively.It was found by the clinical features(gender,age,pathological type,treatment method)that there were significant effects of age,surgical method,preoperative KPS score,pathological classification,postoperative radiotherapy,postoperative chemotherapy and Ki-67 level on postoperative survival(P<0.05),while there were no significant effects of gender,maximum diameter of tumors,calcification and hydrocephalus(P>0.05).The analysis results of COX proportional hazard regression showed that age,surgical method,preoperative KPS,pathological classification,postoperative radiotherapy,postoperative chemotherapy and Ki-67 level were the influencing factors of survival in patients with craniocerebral tumors.Conclusion The prognosis is worse in patients with older age,lower scores of preoperative KPS,higher expression level of Ki-67 and brain metastases.The total resection and postoperative chemoradiotherapy are conducive to improve their prognosis.
作者
杨柳
王蒙
赵培超
丁大领
王俊宽
薛茗予
薛志玲
YANG Liu;WANG Meng;ZHAO Peichao;DING Daling;WANG Junkuan;XUE Mingyu;XUE Zhiling(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2020年第10期876-879,共4页
Chinese Journal of Practical Nervous Diseases
基金
河南省科技攻关项目(编号:172102310058)。
