摘要
微小RNA(microRNA)可通过结合基因的3’-非转录区域降解mRNA或抑制翻译进程,其在化学性肝损伤中的作用已成为近年来毒理学研究的热点之一。酒精性肝损伤是一个全球性的健康问题,酒精在肝脏中的代谢及毒性机理已较为清晰,但microRNA对酒精代谢及肝脏损伤过程的调控机制研究刚刚兴起。本综述主要介绍microRNA对酒精代谢酶、氧化应激及炎症相关基因的调控作用,并探讨其在酒精性肝损伤中的作用机制。
MicroRNA can bind to the 3’ untranslated region(3’UTR) of a target gene and then degrade mature mRNA or suppress relevant translational process, and its roles in chemical induced liver injury have been a toxicological research focus. Alcoholic liver injury becomes a global health burden, and the alcohol metabolism and toxic mechanism in the liver have been almost identified, but research on the regulatory roles of microRNA in alcoholic liver injury is still on the way. In this review, we summarized the biological roles of microRNA in regulating alcohol metabolizing enzymes, oxidative stress genes, and inflammation factors, and the potential regulatory mechanisms disturbing alcoholic liver injury.
作者
王序兵
赵艳洁
于典科
WANG Xu-bing;ZHAO Yanjie;YU Dian-ke(School of Public Health,Qingdao University,Qingdao,Shandong 266000,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2020年第4期406-411,共6页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金项目(81903354)。
关键词
微小RNA
酒精代谢
氧化应激
免疫炎症
肝损伤
microRNA
alcohol metabolism
oxidative stress
immune inflammation
liver injury
