摘要
目的:分析下肢静脉曲张基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶抑制物-2(TIMP-2)水平的表达及价值。方法:选30名下肢静脉曲张患者的静脉组织(观察组)以及30名正常人下肢静脉组织(对照组),用相同方法检测并比较MMP-2及TIMP-2表达水平。结果:光学显微镜下两组MMP-2均可以检测到,但是观察组高于对照组,差异有统计学意义(P<0.05);TIMP-2均可表达,但差异无统计学意义(P>0.05)。结论:下肢静脉曲张患者与MMP-2和TIMP-2的表达异常有关。
Objective:To analyze the expression and value of MMP-2 and TIMP-2 in varicose veins of lower extremities.Methods:Thirty patients with varicose veins of the lower extremity(observation group)and 30 normal human lower extremity vein tissues(control group)were used to detect and compare the expression levels of MMP-2 and TIMP-2.Results:Matrix metalloproteinase-2 was detected in both groups under light microscope,but the observation group was higher than the control group,the difference was statisticallysignificant(P<0.05).Matrix metalloproteinase inhibitor-2 could be expressed,but the difference was not statistically significant(P>0.05).Conclusion:Patients with lower extremity varices are associated with abnormal expression of matrix metalloproteinase-2 and matrix metalloproteinase inhibitor-2.
作者
郑毅
Zheng Yi(Department of Clinical Laboratory, First People's Hospital of Jining City, Jining, Shandong 272000)
出处
《中外女性健康研究》
2020年第6期14-15,共2页
Women＇s Health Research
关键词
基质金属蛋白酶-2
基质金属蛋白酶抑制物-2
表达特征和意义
Matrix metalloproteinase-2
Matrix metalloproteinase inhibitor-2
Expression characteristics and significance
