摘要
目的:探讨玉屏风口服液配伍穴位贴敷联合沙库巴曲缬沙坦对气阴两虚型心力衰竭患者的疗效及对精神、生活质量的影响。方法:将心衰患者150例随机分为联合组和对照组各75例。对照组给予沙库巴曲缬沙坦钠片;联合组在对照组基础上辅以中药制剂玉屏风口服液配伍吴茱萸穴位贴敷。观察2组患者心功能、生活质量及负性情绪情况,随访患者出现主要心血管事件(MACE)和全因死亡情况。结果:治疗前,2组LVEF、6MWT、MLWHFQ评分比较,差异无统计学意义(P>0.05);治疗后联合组LVEF、6MWT水平优于对照组,MLWHFQ评分低于对照组(P<0.05)。治疗前,2组患者NT-proBNP、ICAM-1和ALD水平比较,差异无统计学意义(P>0.05);治疗后联合组NT-proBNP、ICAM-1及ALD水平低于对照组(P<0.05)。治疗前2组SAS、SDS评分比较,差异无统计学意义(P>0.05)。治疗后联合组SAS、SDS评分低于对照组(P<0.05)。治疗期间联合组不良反应发生率为10.67%,对照组为9.33%,组间比较,差异无统计学意义(χ^2=0.074,P=0.785)。随访1年,联合组共出现3例失访,对照组出现2例失访,联合组1年内MACE发生率为28.57%(20/72),对照组为42.46%(31/73),MACE发生风险比较,差异有统计学意义(Log-rankχ^2=4.066,P=0.044)。联合组1年内死亡率为15.27%(11/72),对照组为16.44%(12/73),全因死亡风险比较,差异无统计学意义(Log-rankχ^2=0.062,P=0.804)。结论:沙库巴曲缬沙坦联合玉屏风口服液配伍穴位贴敷能明显改善气阴两虚型心衰患者生活质量和心功能,缓解患者负性情绪,且发生MACE风险更低。
Objective:To discuss the curative effect of Yupingfeng oral liquid and point application combined with sacubitril and valsartan for patients with heart failure of qi-yin deficiency type and its effect on their spirit and quality of life.Methods:A total of 150 cases of patients with heart failure were randomly divided into the combination group and the control group,75 cases in each group.The control group was given sacubitril valsartan sodium tablets,and the combination group was additionally treated with Yupingfeng oral liquid and point application with Fructus Evodiae based on the treatment of the control group.The heart function,quality of life,negative emotions,as well as the major adverse cardiovascular events(MACE)and all-cause death of follow-up patients were observed.Results:Before treatment,compared the scores of LVEF,6 MWT and MLWHFQ between the two groups,there was no significance in the difference(P>0.05).After treatment,the scores of LVEF and 6 MWT in the combination group were better than those in the control group,and the score of MLWHFQ was lower than that in the control group(P<0.05).Before treatment,compared the levels of NTproBNP,ICAM-1 and ALD between the two groups,there was no significance in the difference(P>0.05);after treatment,the above three levels in the combination group were lower than those in the control group(P<0.05).Before treatment,compared the scores of SAS and SDS between the two groups,there was no significance in the difference(P>0.05);after treatment,the above two scores in the combination group were lower than those in the control group(P<0.05).During treatment,the incidence of adverse reactions was 10.67%in the combination group,and 9.33%in the control group,there being no significance in the difference(χ^2=0.074,P=0.785).During one-year follow-up,there were three cases lost in the combination group,and two cases in the control group;the incidence of MACE was 28.57%(20/72)in the combination group,and 42.46%(31/73)in the control group,the difference being significant(Log-
作者
葛海珍
张芸
余瑛
刘松
徐志强
GE Haizhen;ZHANG Yun;YU Ying;LIU Song;XU Zhiqiang
出处
《新中医》
CAS
2020年第9期170-174,共5页
New Chinese Medicine
关键词
心力衰竭
气阴两虚型
玉屏风口服液
穴位贴敷
吴茱萸
中西医结合疗法
负性情绪
生活质量
Heart failure
Qi-yin deficiency type
Yupingfeng oral liquid
Point application
Fructus Evodiae
Integrated Chinese and western medicine therapy
Negative emotions
Quality of life
