摘要
研究鸡血藤水提物中的黄酮类化学成分。采用硅胶、大孔吸附树脂、Sephadex LH-20等柱色谱和反相高效液相色谱分离分析技术对鸡血藤所含的黄酮类化学成分进行系统分离和纯化,并结合谱学技术对所分离的成分进行鉴定。分离得到23个黄酮类化合物和1个色原酮类化合物,分别鉴定为异豆素(1),紫苜蓿烷(2),8-甲基雷杜辛(3),7-羟基二氢黄酮(4),奥刀拉亭(5),艳紫铆素A(6),鹰嘴豆芽素A(7),3′-甲氧基大豆素(8),7-羟基色原酮(9),毛蕊异黄酮(10),柚皮素(11),二氢木豆异黄酮(12),(6aR,11aR)-高丽槐素(13),2′-羟基染料木素(14),(6aR,11aR)-美迪紫檀素-3-O-吡喃葡萄糖苷(15),(-)-表阿夫儿茶素(16),(-)-儿茶素(17),(-)-表儿茶素(18),4′,8-二甲氧基-7-O-β-D-葡萄糖基异黄酮(19),芒柄花苷(20),(-)-没食子儿茶素(21),芦丁(22),大豆苷(23)和圆荚草双糖苷(24)。化合物4,6,8,9,11,12,14~16,19和22~24系首次从该植物中分离得到。
The chemical compounds in water extract of Spatholobi Caulis were further studied. The compounds were systematically isolated and purified by using various separation and analysis techniques including silica gel, macroporous adsorptive resins and Sephadex LH-20 column chromatographies, as well as reversed phase high-performance liquid chromatography(RP-HPLC). Twenty-three flavonoids and one chromone were identified by the spectroscopic analysis techniques combining their physicochemical properties, they were identified as isoduartin(1), sativan(2), 8-O-methylretusin(3), 7-hydroxydihydroflavone(4), odoratin(5), butesuperin A(6), biochanin A(7), 3′-methoxydaidzein(8), 7-hydroxychromone(9), calycosin(10), naringenin(11), dihydrocajanin(12),(6 aR,11 aR)-maackiain(13), 2′-hydroxygenistein(14),(6 aR,11 aR)-medicarpin-3-O-glucopyranoside(15),(-)-epiafzelechin(16),(-)-catechin(17),(-)-epicatechin(18), 4′,8-dimethoxy-7-O-β-D-glucopyranosylisoflavone(19), ononin(20),(-)-gallocatechin(21), rutin(22), daidzin(23) and sphaerobioside(24). Compounds 4, 6, 8, 9, 11, 12, 14-16, 19 and 22-24 were isolated from Spatholobi Caulis for the first time.
作者
刘晓艳
徐嵬
杨秀伟
张鹏
赵威
龚云
刘逆夫
LIU Xiao-yan;XU Wei;YANG Xiu-wei;ZHANG Peng;ZHAO Wei;GONG Yun;LIU Ni-fu(State Key Laboratory of Natural and Biomimetic Drugs,Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Zhuzhou Qianjin Pharmaceutical Co.,Ltd.,Zhuzhou 412000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第6期1384-1392,共9页
China Journal of Chinese Materia Medica
基金
国家中药标准化项目(2YB2H-C-HUN-21)。
关键词
鸡血藤
黄酮
异黄酮
化学成分
Spatholobi Caulis
flavonoids
isoflavones
chemical compounds
