摘要
【指示性摘要】IL-6由肿瘤细胞自分泌,与肿瘤侵袭性密切相关;TNF-α在机体肿瘤免疫应答中起到了重要作用,可引起肿瘤细胞坏死,且可诱导IL-6的表达;IFN-γ具有抗病毒,抗肿瘤和免疫调控的作用;IL-10具有双向免疫调节作用,在肿瘤环境中对免疫应答具有负向调节作用,同时也能发挥刺激作用。上述细胞因子在弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生发展中或起到协同作用,并可能作为DLBCL诊断及预后的指标。
IL-6 is autocrine by tumor cells and is closely related to tumor invasion.TNF-αplays an important role in tumor immune response,which can cause tumor cell necrosis and induce IL-6 expression.IFN-γhas anti-virus,anti-tumor and immune regulation.IL-10 has a two-way immunomodulatory effect,which has a negative regulatory effect on the immune response in the tumor environment,and can also exert a stimulating effect.The above cytokines may play a synergistic role in the development of diffuse large B cell lymphoma(DLBCL)and may serve as an indicator for the diagnosis and prognosis of DLBCL.
作者
包雪娇
王树叶
Bao Xuejiao;Wang Shuye(Department of Hematology,First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China)
出处
《现代肿瘤医学》
CAS
2020年第12期2141-2145,共5页
Journal of Modern Oncology
基金
国家重点基础研究发展计划子课题(编号:2012CBA01303)。
