摘要
目的观察乙酰谷酰胺联合依达拉奉治疗脑梗死的疗效及对患者血清半乳糖凝集素-3(Galectin-3)、神经肽Y(NPY)表达的影响。方法纳入我院2017年8月~2019年7月收治的67例脑梗死患者,采用随机数字表法分为观察组34例和对照组33例。两组均给予神经内科常规综合治疗,在此基础上,对照组采用依达拉奉治疗,观察组采用乙酰谷酰胺+依达拉奉治疗,疗程均为2周。比较两组疗效、神经功能及血清Galectin-3、NPY表达含量变化情况。结果观察组总有效率高于对照组(94.12%vs 75.76%),差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分低于对照组(P<0.05);观察组血清Galectin-3、NPY表达含量低于对照组(P<0.05)。结论乙酰谷酰胺联合依达拉奉可明显促进脑梗死患者神经功能恢复,且可明显下调血清Galectin-3、NPY表达含量。
Objective To observe the efficacy of acetylglutamine combined with edaravone in the treatment of cerebral infarction and its influence on the expression of Galectin-3 and neuropeptide Y(NPY).Methods A total of 67 patients with cerebral infarction treated in our hospital between August 2017 and July 2019 were enrolled in this study.They were divided into observation group(n=34)and control group(n=33)using random number table method.Both groups were given conventional comprehensive treatment in neurology department.On the basis of this,the control group was treated with edaravone for 2 weeks,and the observation group was treated with acetylglutamine+edaravone for 2 weeks.The efficacy,neurological function,and changes of serum Galectin-3 and NPY expression in the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(94.12%vs 75.76%),and the difference was statistically significant(P<0.05).After treatment,the national institutes of health stroke scale(NIHSS)score of the observation group was lower than that of the control group(P<0.05).The expression levels of Galectin-3 and NPY were lower than those in the control group(P<0.05).Conclusion Acetylglutamine combined with edaravone can significantly promote the recovery of neurological function in patients with cerebral infarction,and can significantly reduce the expression levels of serum Galectin-3 and NPY.
作者
王昕莉
WANG Xinli(Department of Neurology,Jiamusi Maternal and Child Health Hospital in Heilongjiang Province,Jiamusi154002,China)
出处
《中国现代医生》
2020年第10期48-50,54,共4页
China Modern Doctor
