摘要
人神经肽Y(NPY)是36个氨基酸残基组成的高效神经递质和生物活性多肽,主要由中枢和外周神经系统的神经元表达与分泌。非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝损伤,进一步发展可转化成肝纤维化、肝硬化及肝细胞癌。NPY可通过调控能量代谢和炎症等途径参与NAFLD的发生。本文对NPY在NAFLD不同病程阶段,通过中枢神经系统及外周介导肝脏病变的分子机制进行综述。
Human neuropeptide Y(NPY) is a highly efficient neurotransmitter and bioactive peptide composed of 36 amino acid residues.It is mainly expressed and secreted by neurons in the central and peripheral nervous system.Nonalcoholic fatty liver disease(NAFLD) is a metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility.It can be further developed into liver fibrosis, cirrhosis and hepatocellular carcinoma.NPY may participate in NAFLD by regulating energy metabolism and inflammation.The molecular mechanisms of NPY mediated liver disease through the central nervous system and the periphery at different stages of NAFLD are reviewed.
作者
李小溪
丁宇
朱玲
贺梦菲
左夏林
欧阳平
Li Xiaoxi;Ding Yu;Zhu Ling;He Mengfei;Zuo Xialin;Ouyang ring(Department of Health Management,Nanfang Hospital,Southern Medical University,Guangzhou 510515;The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260)
出处
《国际老年医学杂志》
2022年第5期616-619,共4页
International Journal of Geriatrics
基金
国家自然科学基金项目(81501952)。
关键词
神经肽Y
非酒精性脂肪性肝病
分子机制
Neuropeptide Y
Non-alcoholic fatty liver disease
Molecular mechanism
