摘要
目的观察喘泰颗粒联合布地奈德治疗儿童哮喘急性发作的临床效果。方法选择2016年10月-2019年10月在郑州大学第二附属医院治疗的哮喘急性发作患儿199例,随机分成对照组(100例)和治疗组(99例)。对照组雾化吸入吸入用布地奈德混悬液,1 mg/次,2次/d。治疗组在对照组治疗基础上口服喘泰颗粒,3 g/次,4次/d。两组均连续治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患儿用力肺活量(FVC)、最大呼气流量(PEF)、一秒用力呼气容积(FEV1)、免疫球蛋白G(IgG)、免疫球蛋白E(IgE)、免疫球蛋白M(IgM)、白介素-8(IL-8)和白介素-4(IL-4)水平,及临床症状改善时间。结果治疗后,对照组临床有效率为74.00%,显著低于治疗组的94.95%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿FVC、PEF和FEV1水平均明显升高(P<0.05),且治疗组患儿明显比对照组高(P<0.05)。治疗后,两组患儿IgG和IgM水平均明显升高(P<0.05),而IgE水平均明显降低(P<0.05),且治疗组患儿IgG、IgE和IgM水平明显比对照组好(P<0.05)。治疗后,两组患儿IL-8和IL-4水平均明显降低(P<0.05),且治疗组患儿明显低于对照组(P<0.05)。治疗后,治疗组患儿肺部哮鸣音、咳嗽、喘憋改善时间明显比对照组早(P<0.05)。结论喘泰颗粒联合布地奈德治疗小儿哮喘急性发作,可改善患儿临床症状,提高肺功能,改善机体免疫水平,临床疗效较好。
Objective To observe the clinical effect of Chuantai Granules combined with budesonide in treatment of acute attack of asthma in children. Methods Children(199 cases) with acute attack of asthma in the Second Affiliated Hospital of Zhengzhou University from October 2016 to October 2019 were randomly divided into control(100 cases) and treatment(99 cases) groups. Children in the control group were atomization inhalation administered with Rupatadine Fumarate Tablets, 1 mg/time, twice daily. Children in the treatment group were po administered with Chuantai Granules on the basis of the control group, 3 g/time, four times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the level of FVC, PEF, FEV1, IgG, IgE, IgM, IL-8 and IL-4, the improvement time of clinical symptom in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 74.00%, which was significantly lower than 94.95% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the level of FVC, PEF, and FEV1 in two groups was significantly increased(P < 0.05), and which in the treatment group was significantly higher than that in the control group(P < 0.05). After treatment, the level of IgG and IgM in two groups was significantly increased(P < 0.05), but the IgE level was significantly decreased(P < 0.05), and the IgG, IgE, and IgM level in the treatment group was significantly better than that in the control group(P < 0.05). After treatment, the level of IL-8 and IL-4 in two groups was significantly decreased(P < 0.05), and which in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the improvement time of lung wheezing, coughing, wheezing in the treatment group was significantly earlier than that in the control group(P < 0.05). Conclusion Chuantai Granules combined with budesonide in treatment of acute attack of asthma in children can improve
作者
王金永
吕伟刚
张广阳
朱永杰
WANG Jin-yong;LÜWei-gang;ZHANG Guang-yang;ZHU Yong-jie(Department of Pediatrics,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Pediatrics,the First Affiliated Hospital of Henan University of TCM,Zhengzhou 450000,China;Department of Pediatrics,No.988 Hospital of the Chinese PLA joint logistics support force,Zhengzhou 450000,China;Department of Emergency,Zhengzhou Children’s Hospital,Zhengzhou 450000,China)
出处
《现代药物与临床》
CAS
2020年第4期663-667,共5页
Drugs & Clinic
基金
河南省医学科技攻关项目(201403258)。
