摘要
目的分析不同剂量人免疫丙种球蛋白对重症肺炎患儿临床症状及免疫功能的影响。方法选取于2017年6月-2019年3月间洛阳市妇女儿童医疗保健中心收治的重症肺炎患儿84例,用随机数字表法分为两组,每组各42例。两组患儿均实施常规治疗,对照组接受400 mg/(kg·d)的人免疫丙球蛋白治疗,观察组予以1 g/(kg·d)的人免疫丙球蛋白治疗。比较两组症状消失时间、住院时间、免疫功能及不良反应发生情况等。结果观察组与对照组比较,患儿气促、咳嗽、啰音及发热症状消失时间与住院时间均较短,治疗后患儿CD4^+、CD4^+/CD8^+水平均较高,CD8^+较低,差异有统计学意义(P<0.05)。结论对重症肺炎患儿使用大剂量人免疫丙种球蛋白治疗,可有效改善临床症状,缩短住院时间,增强患儿免疫功能,提升抗病能力,用药安全性较高。
Objective To analyze the effect of different doses of human immunoglobulin on clinical symptoms and immune function in children with severe pneumonia.Methods 84 children with severe pneumonia in the hospital from June, 2017 to March, 2019, were randomly divided into two groups. Both groups were treated with routine treatment. The control group was treated with human immunoglobulin of 400 mg/(kg·d), and the observation group was treated with human immunoglobulin of 1 g/(kg·d). The disappearance time, hospitalization time, immune function and adverse reactions were compared between the two groups.Results Compared with the control group, the disappearance time and hospitalization time of shortness of breath, cough,rale and fever in the observation group were shorter than those in the control group. After treatment, the level of CD4^+,CD4^+/CD8^+was higher and CD8^+was lower, the difference was statistically significant(P<0.05).Conclusion The treatment of severe pneumonia with high dose human immunoglobulin can effectively promote the improvement of clinical symptoms, shorten the hospitalization time, enhance the immune function of children, improve their disease resistance, and the safety of drug use is high.
作者
权亚利
QUAN Li-ya(Luoyang Women and Children Medical and Health Center,Henan,Luoyang,471000,China)
出处
《黑龙江医学》
2020年第5期627-629,共3页
Heilongjiang Medical Journal
