摘要
目的观察早期应用不同剂量舍曲林干预脑梗死患者卒中后抑郁(PSD)的效果。方法选取2016年2月~12月南京医科大学附属苏州医院收治的首发急性脑梗死患者101例,采用随机数字表法将其分为三组,分别为干预A组35例,干预B组32例和对照组34例,三组均给予脑梗死常规治疗,干预A组加用舍曲林50 mg/d,干预B组加用舍曲林100 mg/d,对照组为空白对照,疗程3个月。比较三组治疗1、3个月PSD发生率及焦虑抑郁(HAMD)评分。结果对照组、干预A组、干预B组治疗1个月PSD发生率分别为20.59%、17.14%、15.63%,三组比较,差异无统计学意义(P>0.05);对照组、干预A组、干预B组治疗3个月PSD发生率分别为32.35%、14.29%、6.25%,干预B组PSD发生率低于对照组,差异有统计学意义(P<0.05);对照组、干预A组、干预B组治疗1个月HAMD评分比较,差异无统计学意义(P>0.05),治疗3个月干预A组、干预B组HAMD评分低于对照组,差异有统计学意义(P<0.05)。结论舍曲林早期干预急性脑梗死患者3个月后可改善其抑郁程度,较大剂量舍曲林(100 mg/d)干预3个月可降低PSD发生率。
Objective To observe the effect of early application of different doses of sertraline on post-stroke depression(PSD)in patients with cerebral infarction.Methods A total of 101 patients with first acute cerebral infarction admitted to Suzhou Hospital of Nanjing Medical University from February to December 2016 were selected and divided into three groups by random number table method,which were 35 patients in intervention group A,32 patients in intervention group B,and 34 cases in the control group,all three groups were given conventional treatment of cerebral infarction,intervention group A was added with sertraline 50 mg/d,intervention group B was added with sertraline 100 mg/d,the control group was a blank control,and the course of treatment was 3 month.The incidence of PSD and anxiety and depression(HAMD)scores were compared between the three groups for the course of 1 and 3 months.Results The one-month PSD incidence rates in the control group,intervention group A,and intervention group B were 20.59%,17.14%,and 15.63%,respectively.There was no significant difference between the three groups(P>0.05).The incidence of PSD in the control group,intervention group A,and intervention group 3 months was 32.35%,14.29%,and 6.25%,respectively.The incidence of PSD in intervention group B was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the HAMD score between the control group,intervention group A,and intervention group at 1 month(P>0.05).The HAMD scores of intervention group A and intervention group B at 3 months were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Sertraline early intervention in patients with acute cerebral infarction after 3 months can improve their degree of depression,a larger dose of sertraline(100 mg/d)intervention for 3 months can reduce the incidence of PSD.
作者
叶欢
周华
沈蓉
徐元
刘源
赵中
YE Huan;ZHOU Hua;SHEN Rong;XU Yuan;LIU Yuan;ZHAO Zhong(Department of Neurology,Suzhou Ninth People's Hospital,Suzhou 215200,Jiangsu,China;Department of Neurology,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215001,Jiangsu,China)
出处
《医学信息》
2020年第6期141-143,共3页
Journal of Medical Information
基金
江苏省卫生计生委科研课题(编号:H201651)
苏州市科技计划项目(编号:SYS201650)。
关键词
舍曲林
早期干预
脑梗死
卒中后抑郁
Sertraline
Early intervention
Cerebral infarction
Post-stroke depression
