摘要
目的:脑卒中后抑郁能明显影响患者康复锻炼的主动性,加重功能缺损,观察抗抑郁药物氟西汀对其的预防作用以及对神经功能恢复的影响。方法:选取在苏州大学附属第一医院神经内科住院的71例初发脑卒中患者,除外意识障碍、失语、精神病史者。随机分为对照组与治疗组,治疗组加用氟西汀20mg/d。应用汉密顿抑郁量表(HAMD)及神经功能缺损评分量表(SSS)分别于入院时、8周进行评定。结果:治疗前两组HAMD和SSS评分差异无显著性意义(P>0.05)。治疗后治疗组HAMD和SSS评分分别为14.28±2.31,10.41±6.36,对照组为20.32±3.38,14.43±7.91,两组比较差异有非常显著性意义(t=3.87,4.09,P<0.01)。结论:脑卒中后早期应用抗抑郁药物治疗能明显减少脑卒中后抑郁的发生,加快患者神经功能的康复。
AIM:Depression after stroke can obviously influence the activity of rehabilitation in the patients, and deteriorate the functional impairment. The purpose of the study was to observe the preventive effect of antidepressant drug fluoxetine and its effect on neurological functional rehabilitation. METHODS: Seventy one patients with first stroke, who were hospitalized in the Department of Neurology,First Affiliated Hospital of Suzhou University, and had no conscious disturbance, anepia and history of mental disease were excluded, were randomly assigned into treatment group (fluoxetine 20 mg per day) and control group.All the patients were evaluated with Hamilton depression rating scale(HAMD) and Scandivanian stroke scale(SSS) at admission and 8 weeks after treatment respectively. RESULTS: There were no significant differences in the scores of HAMD and SSS between the two groups before treatment(P >0.05). After treatment, the scores of HAMD and SSS in the treatment group (14.28±2.31,10.41±6.36) had very significant differences from those in the control group (20.32±3.38,14.43±7.91) (t=3.87, 4.09, P< 0.01). CONCLUSION: Early antidepressant treatment in the stroke patients can obviously reduce the prevalence of post stroke depression and improve the rehabilitation of neurological function.
出处
《中国临床康复》
CSCD
2004年第28期6016-6017,共2页
Chinese Journal of Clinical Rehabilitation
