摘要
【目的】观察脐针治疗脾虚气滞证功能性消化不良餐后不适综合征的临床疗效及安全性。【方法】将90例脾虚气滞证功能性消化不良餐后不适综合征患者,随机分为治疗组和对照组,每组各45例。治疗组给予脐针治疗,对照组给予常规针刺治疗,均为隔日治疗1次,1周治疗3次,连续治疗4周。治疗4周后,比较2组患者治疗前后中医症状积分和胃肠激素血清降钙素基因相关肽(CGRP)、胃动素(MTL)、饥饿素(Ghrelin)含量的变化情况,并评价2组的临床疗效及安全性。【结果】(1)治疗后,2组患者的主要中医症状积分明显改善(P<0.05),且治疗组在改善胃脘疼痛、胃脘胀满、食少纳呆及总积分方面均明显优于对照组,差异均有统计学意义(P<0.01),而食后胃脘不适、嗳气反酸、烧心、大便稀溏等症状与对照组比较,差异无统计学意义(P>0.05)。(2)治疗组愈显率为64.44%(29/45),对照组为17.78%(8/45),治疗组愈显率明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的CGRP、MTL、Ghrelin含量明显改善(P<0.05),且治疗组在改善CGRP、MTL、Ghrelin含量方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)安全性评价:2组患者均未出现严重不良事件,治疗后基本生命体征无明显异常。【结论】脐针疗法治疗脾虚气滞型功能性消化不良餐后不适综合征,能明显改善患者中医症状积分,调节胃肠激素血清CGRP、MTL、Ghrelin含量,疗效显著。
Objective To observe the clinical efficacy and safety of navel acupuncture in treating postprandial distress syndrome of functional dyspepsia with qi stagnation due to spleen deficiency syndrome.Methods Ninety patients with postprandial distress syndrome of functional dyspepsia with qi stagnation due to spleen deficiency syndrome were randomly divided into treatment group and control group,45 cases in each group.The treatment group received navel acupuncture therapy,and the control group received conventional acupuncture therapy once every two days,3 times for one week,and the treatment lasted 4 continuous weeks.After 4 weeks of treatment,the changes in scores of traditional Chinese medicine(TCM)symptoms,and contents of calcitonin gene-related peptide(CGRP),motilin(MTL)and Ghrelin were observed in the two groups before and after treatment,and the clinical efficacy and safety in the two groups were evaluated.Results(1)After treatment,the scores of main TCM symptoms in the two groups were improved(P<0.05),and the improvement in scores of stomachache,epigastric flatulence,inappetence and anorexia and total scores in the treatment group was superior to that in the control group,the difference being significant(P<0.01).But there were no significant differences in scores of symptoms of epigastric discomfort,belching and acid regurgitation,heartburn and loose stool in the two groups(P>0.05).(2)The markedly effective rate was 64.44%(29/45)in the treatment group,and was 17.78%(8/45)in the control group.The markedly effective rate in the treatment group was superior to that in the control group(P<0.05).(3)After treatment,the contents of CGRP,MTL,and Ghrelin were improved in the two groups(P<0.05),and the improvement in contents of CGRP,MTL,and Ghrelin in the treatment group was superior to that in the control group(P<0.05).(4)Safety evaluation results showed that no serious adverse events,and no obviously abnormal basic vital signs after treatment in the two groups.Conclusion Navel acupuncture is significantly effective fo
作者
胡学军
李颖文
张应杰
吴子安
陈水林
陈璐
HU Xue-Jun;LI Ying-Wen;ZHANG Ying-Jie;WU Zi-An;CHEN Shui-Lin;CHEN Lu(The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2020年第5期890-894,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广州市荔湾区科技计划项目(编号:201704047)。
关键词
脐针
脾虚气滞
功能性消化不良
餐后不适综合征
临床疗效
navel acupuncture
qi stagnation due to spleen deficiency
functional dyspepsia(FD)
postprandial distresssyndrome(PDS)
clinical effects
