摘要
目的:分析不同基因分型的Hp感染的健康体检人群胃黏膜功能之间的差异。方法:选取我院体检中心检测的Hp阳性的无症状健康人群患者140例作为研究对象,根据血清CagA和VacA蛋白检测结果,将Hp菌株分为:Ⅰ型、Ⅱ型和中间表达型(简称中间型),同时选取50例Hp阴性的健康体检者设为对照组,收集所有患者PGⅠ、PGⅡ、PGR、G-17检测结果,比较四组患者间胃黏膜功能的差异。结果:四组患者间PGⅠ、PGⅡ、G-17水平存在统计学差异(P<0.05),而PGR水平无统计学差异(P>0.05)。SNK-q检验结果显示,Ⅰ型Hp和中间型Hp人群PGⅠ、PGⅡ水平低于对照组和Ⅱ型Hp组(P<0.05),G-17水平高于对照组和Ⅱ型Hp组(P<0.05),Ⅰ型Hp组人群PGⅠ、PGⅡ和G-17水平与中间组Hp间均无统计学差异(P>0.05)。对照组和Ⅱ型Hp组间PGⅠ、PGⅡ和G-17水平无差异(P>0.05)。结论:不同分型的Hp感染对健康人群胃黏膜功能的影响存在一定差异,通过Hp分型检测有助于评估胃黏膜炎症、萎缩以及癌变的状态和风险。
Objective:To analyze the differences of gastric mucosal function in healthy people with different genotypes of Helicobacter pylori(Hp)infection.Methods:140 cases of asymptomatic healthy people with Hp infection were selected,according to the result of CagA and VacA serum protein detection,Hp strains were divided into:typeⅠ,typeⅡ,middle type,50 cases of Hp negative health examination were setted as control group,collect the data of PGⅠ,PGⅡ,PGR,G-17 test results,comparing differences between four groups.Results:There were statistical differences of PGⅠ,PGⅡand G-17 between four groups(P<0.05),While there with no statistical differences of PGR between four groups(P>0.05).SNK-q test showed that the PGⅠand PGⅡin typeⅠand middle type people were lower than the control group and typeⅡHp group,while G-17 were higher than the control group and typeⅡHp group,difference has statistical significance(P<0.05);what’s more,there were no statistical significance of PGⅠ,PGⅡand G-17 level with typeⅠand middle type people(P>0.05),as well as TypeⅡHp group and the negative control group(P>0.05).Conclusion:There has differences in the influence of different types of Hp infection on gastric mucosal function in healthy people.Hp typing can help to assess the status and risk of gastric mucosal inflammation,atrophy and cancer.
作者
方东
FANG Dong(The Second People’s Hospital of Hefei City,Anhui Province 230000)
出处
《医学理论与实践》
2020年第10期1565-1567,共3页
The Journal of Medical Theory and Practice
基金
合肥市卫生健康应用医学研究重点项目(合卫科教[2019]172号)。
