摘要
青光眼睫状体炎综合征(Posner-Schlossman syndrome,PSS)是轻度非肉芽肿性前葡萄膜炎继发眼压升高的一种疾病,病因及发病机制尚不明确。多以单眼反复发作的轻度前房炎症伴随急性高眼压为特征,可产生不可逆性视神经损害。病因学包括病毒及幽门螺旋杆菌感染、免疫、基因易感性等,从前列腺素升高、房水动力学系数改变、代谢组学等角度可推测眼压升高的机制。抗炎和降眼压是临床治疗的主要手段,青光眼手术指征仍有争议,联合抗病毒治疗对减少疾病复发有一定效果。
Glaucomato-cyclitic syndrome,or Posner-Schlossman Syndrome(PSS),is a secondary open angle glaucoma characterized by acute attacks of mild non-granulomatous anterior uveitis.Its etiology and pathogenesis are unknown.Manifestations of recurrently raised unilateral intraocular pressure(IOP),relatively mild anterior chamber inflammation are present in PSS,which can result in irreversible optic nerve damage.The etiology includes infections of virus and Helicobacter pylori,immunity,genes,etc.The pathogenesis of ocular hypertension can be speculated by prostaglandin,coefficient of outflow facility,metabonomics of aqueous humor,but more researches are needed.At present,anti-inflammatory and reducing IOP are the main means of clinical treatment.Anti-glaucoma surgical indications are still controversial,but combined antiviral therapy has certain effects on reducing recurrence.
作者
林川琦
江俊宏
张绍丹
梁远波
Lin Chuanqi;Jiang Junhong;Zhang Shaodan;Liang Yuanbo(The Eye Hospital,Wenzhou Medical University,Wenzhou 325000,China)
出处
《国际眼科纵览》
2020年第2期73-81,共9页
International Review of Ophthalmology
