摘要
目的:采用影像检查易与早期肺癌相混淆的良性病变为对照,探讨癌胚抗原(CEA)、细胞角蛋白19片段抗原(CYFRA21-1)、糖链抗原125(CA125)三种肿瘤标志物联合检测在早期肺癌诊断和病理分型中的应用价值。方法:在2017年1月至2018年12月间,于西安交通大学第二附属医院收集非小细胞肺癌的患者血清47例,肺部良性病变患者血清40例。采用电化学发光免疫分析法检测血清肿瘤标志物的水平。结果:肺癌组三种标志物水平显著高于肺部良性病变组。对鳞癌和腺癌病理类型的鉴别诊断,CA125最有意义。三种标志物对肺癌的阳性率,联合检测显著高于单项检测,而联合检测的特异度显著低于CEA和CA125,上述差异均具有统计学意义(P<0.05)。三项均阳性的肺癌,腺癌所占比例显著大于鳞癌;而当CYFRA21-1阳性,同时CA125阴性时,鳞癌所占比例显著大于腺癌。结论:三种标志物联合检测较单项检测可明显提高早期肺癌检测的敏感度,而特异度却显著降低。三种标志物综合分析对早期肺癌的诊断和病理类型的鉴别都具有重要的参考价值。
Objective Using benign lesions that are easily confused with early lung cancer by imaging examination as control,to evaluate the application of combined detection of CEA,CYFRA21-1 and CA125 in the diagnosis,pathological types of lung cancer.Methods Serums were collected in the second affiliated hospital of Xi'an Jiao Tong University,between January 2017 and December 2018 including:47 patients with NSCLC,40 patients with benign lung diseases.The concentrations of tumor markers in serum were detected by electrochemical immunofluorescence.Results Serum levels of three in the lung cancer group were higher than those in the benign lung lesions group.CA125 is the most valuable marker for differential diagnosis of squamous cell carcinoma and adenocarcinoma.The positive rate of three markers combined detection for lung cancer was significantly higher than that of anyone single detection.The specificity of combined detection was significantly lower than that of CEA and CA125,the above differences have statistical significance(P<0.05).The incidence of adenocarcinoma was significantly higher when all three items were positive than that of squamous cell carcinoma,but when CYFRA21-1 was positive and CA125 was negative,the incidence of squamous cell carcinoma was significantly higher than that of adenocarcinoma.Conclusion The combined detection of three tumor markers can significantly improve the sensitivity of early lung cancer detection compared with single detection,but the specificity is significantly reduced.Comprehensive analysis of the three markers has important reference value for early diagnosis and differentiation of pathological types of lung cancer.
出处
《科技视界》
2020年第12期169-172,共4页
Science & Technology Vision
基金
陕西省教育厅2018年度科学研究计划项目(18JK0658)。
关键词
肺癌
肿瘤标志物
研究对象
联合检测
Lung cancer
Tumor markers
Research subjects
Combined detection
