摘要
目的探讨红细胞分布宽度(red blood cell distribution width,RDW)、平均血小板体积(mean platelet volume,MPV)及癌抗原125(cancer Antigen 125,CA125)联合检测对卵巢良恶性肿瘤的鉴别意义。方法选取2010年1月—2019年1月徐州医科大学附属医院收治的盆腔肿瘤患者共607例为研究对象,根据术后病理切片分为卵巢癌组(268例)和卵巢良性肿瘤组(339例),选取同时期健康体检者200例作为对照,回顾分析3组患者的CA125及RDW、MPV水平,探讨卵巢癌患者术前RDW及MPV与临床病理特征的相关性,采用ROC曲线分析联合检测鉴别卵巢癌和卵巢良性肿瘤患者的灵敏度与特异度。结果卵巢癌组、卵巢良性肿瘤组和对照组RDW分别为(13.86±1.22)%、(12.82±0.83)%和(11.91±0.99)%,差异具有统计学意义(P<0.01);MPV分别为(9.29±1.36)、(10.89±0.94)和(12.26±1.55)fl,差异具有统计学意义(P<0.01)。卵巢癌患者术前RDW水平与国际妇产科联盟手术病理分期(FIGO,2014年)呈正相关(r=0.725,P=0.024);术前MPV水平与FIGO分期呈负相关(r=-0.831,P=0.010)。RDW、MPV和CA125联合检测鉴别卵巢癌和卵巢良性肿瘤的灵敏度、特异度和AUC分别为83.0%、91.2%和0.931(0.907-0.955)。结论RDW、MPV和CA125联合检测可在临床上有效鉴别卵巢癌和卵巢良性肿瘤。
Objective To explore the significance of red blood cell distribution width(RDW),mean platelet volume(MPV),and cancer antigen 125(CA125)combined detection for the differenciation of benign and malignant ovarian tumors.Methods A total of 607 patients with pelvic mass admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to January 2019 were selected as the research subjects,including 268 patients with ovarian cancer(ovarian cancer group)and 339 patients with benign ovarian tumors(benign ovarian tumor group).The selected subjects were confirmed by pathology.A total of 200 healthy subjects in the same period were selected as the control group.The levels of CA125,RDW and MPV in the three groups were analyzed retrospectively,and the correlation between preoperative RDW and MPV and clinicopathological characteristics of patients with ovarian cancer was studied.The sensitivity and specificity of ROC curve analysis were used to identify patients with ovarian cancer and benign ovarian tumor.Results The RDW of the ovarian cancer group,benign ovarian tumor group and control group were(13.86±1.22)%,(12.82±0.83)% and(11.91±0.99)%,respectively,the difference was statistically significant(P<0.001),and the MPV of the ovarian cancer group,benign ovarian tumor group and control group were(9.29±1.36)fl,(10.89±0.94)fl and(12.26±1.55)fl,respectively,the difference was statistically significant(P<0.001).The preoperative RDW level of ovarian cancer patients was positively correlated with the International Obstetrics and Gynecology Union surgical pathological stage(FIGO,2014)(r=0.725,P=0.024),while the preoperative MPV level was negatively correlated with the FIGO stage(r=-0.831,P=0.010).The sensitivity,specificity,and AUC of RDW,MPV,and CA125 in identifying ovarian cancer and benign ovarian tumors were 83.0%,91.2%,and 0.931(0.907-0.955),respectively.Conclusions The combined detection of RDW,MPV and CA125 can effectively distinguish ovarian cancer and benign ovarian tumor.
作者
杨焕
周臣
陆晓媛
经莉
YANG Huan;ZHOU Chen;LU Xiaoyuan;JING Li(Graduate School,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;Department of Obstetrics and Gynecology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002)
出处
《徐州医科大学学报》
CAS
2020年第2期137-141,共5页
Journal of Xuzhou Medical University
基金
徐州市科技局项目(KC18057)。
