摘要
目的:探讨rt-PA静脉溶栓联合人尿激肽原酶治疗急性缺血性脑卒中的临床效果及对预后的影响。方法:应用随机数字表法将2018年8月-2019年6月笔者所在医院收治的80例急性缺血性脑卒中患者分为观察组及对照组,发病时间<4.5 h,观察组40例采用rt-PA静脉溶栓联合人尿激肽原酶治疗,对照组40例采用rt-PA静脉溶栓治疗。对比两组治疗前后NIHSS评分、治疗有效率及并发症发生率,并通过改良Rankin量表评分对比两组预后情况。结果:两组治疗后NIHSS评分较治疗前明显下降,且试验组低于对照组(P<0.05);观察组治疗有效率为75.00%,明显高于对照组的50.00%(P<0.05);观察组预后良好率为67.50%,明显高于对照组的42.50%(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:rt-PA静脉溶栓联合人尿激肽原酶治疗急性缺血性脑卒中的临床效果显著,可明显改善患者预后,且未增加并发症发生率。
Objective:To explore the clinical effect of rt-PA intravenous thrombolysis combined with Human Urinary Kallidinogenase in the treatment of acute ischemic stroke and its influence on the prognosis of patients.Method:A total of 80 patients with acute ischemic stroke admitted to our hospital from August 2018 to June 2019 were divided into the observation group and the control group according to the random number table method.All patients were within 4.5 hours of onset.And 40 cases in the observation group were treated with rt-PA intravenous thrombolysis combined with Human Urinary Kallidinogenase,and 40 cases in the control group were treated with rt-PA intravenous thrombolysis.The NIHSS scores before and after treatment,effective rate,incidence of complications of the two groups were compared,and the prognosis of the two groups was compared by the score of modified Rankin scale.Result:NIHSS scores in the two groups decreased significantly after treatment compared with those before treatment,and the observation group were lower than those of the control group (P<0.05).The effective rate was 75.00% in the observation group,which was significantly higher than 50.00% of the control group (P<0.05).The rate of favorable prognosis of the observation group was 67.50%,which was significantly higher than 42.50% of the control group (P<0.05).The incidence of complications was compared between the two groups,and the difference was not statistically significant (P>0.05).Conclusion:rt-PA intravenous thrombolysis combined with Human Urinary Kallidinogenase has a significant clinical effect in the treatment of acute ischemic stroke,and can significantly improve the prognosis of patients,and does not increase the incidence of complications.
作者
邹东勇
蒋波
ZOU Dongyong;JIANG Bo(The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China)
出处
《中外医学研究》
2020年第10期44-46,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
