摘要
目的研究重组组织型纤溶酶原激活物(rt-PA)静脉溶栓联合大株红景天对急性脑梗死患者血清S100β蛋白及C反应蛋白(CRP)水平的影响。方法120例进行rt-PA静脉溶栓治疗的急性脑梗死患者,按随机表法分为对照组和研究组,各60例。对照组采取神经内科常规溶栓治疗,研究组在对照组的基础上给予大株红景天注射液静脉滴注治疗。比较两组患者治疗前及治疗后48 h、72 h、7 d、15 d的美国国立卫生研究院卒中量表(NIHSS)评分、RANKIN量表(MRS)评分、血清S100β蛋白水平、CRP水平。结果研究组患者治疗后48 h、72 h、7 d、15 d的NIHSS评分分别为(13.61±2.04)、(9.54±1.92)、(9.06±1.71)、(6.12±1.53)分,均低于治疗前的(18.19±2.14)分;对照组患者治疗后48 h、72 h、7 d、15 d的NIHSS评分分别为(14.34±2.17)、(9.93±1.96)、(9.42±1.84)、(8.36±1.66)分,均低于治疗前的(18.36±2.31)分,且研究组患者治疗后15 d的NIHSS评分低于对照组,差异均具有统计学意义(P<0.05)。研究组患者治疗后48 h、72 h、7 d、15 d的MRS评分分别为(3.24±0.82)、(2.87±0.77)、(2.71±0.54)、(1.99±0.32)分,均低于治疗前的(4.19±0.91)分;对照组患者治疗后48 h、72 h、7 d、15 d的MRS评分分别为(3.85±0.84)、(3.10±0.81)、(2.87±0.75)、(2.56±0.55)分,均低于治疗前的(4.23±0.89)分,且研究组患者治疗后15 d的MRS评分低于对照组,差异均具有统计学意义(P<0.05)。两组患者治疗后48 h、72 h、7 d、15 d血清S100β蛋白及CRP水平均低于治疗前,且治疗后15 d研究组低于对照组,差异均具有统计学意义(P<0.05)。结论rt-PA静脉溶栓联合大株红景天治疗急性脑梗死可以改善患者的生活质量、血清S100β蛋白及CRP水平,对提高患者健康水平、促进社会健康有着非常重要的意义。
Objective To study the effect of recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis combined with Sofren injection on serum S100βprotein and C-reactive protein(CRP)levels in patients with acute cerebral infarction.Methods A total of 120 patients with acute cerebral infarction treated by rt-PA intravenous thrombolysis were divided into control group and research group by random number table method,with 60 cases in each group.The control group was treated by conventional thrombolysis in neurology,and the research group was treated by intravenous infusion of Sofren injection on the basis of the control group.The National Institutes of Health stroke scale(NIHSS)score,modified RANKIN scale(MRS)score,serum S100βprotein and CRP levels before treatment and after 48 h,72 h,7 d and 15 d of treatment were compared between the two groups.Results After 48 h,72 h,7 d and 15 d of treatment,NIHSS score of the research group were(13.61±2.04),(9.54±1.92),(9.06±1.71)and(6.12±1.53)points respectively,which were all lower than that before treatment(18.19±2.14)points.NIHSS score of the research group were(14.34±2.17),(9.93±1.96),(9.42±1.84)and(8.36±1.66)points respectively,which were all lower than that before treatment(18.36±2.31)points.After 15 d of treatment,NIHSS score of the research group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 48 h,72 h,7 d and 15 d of treatment,MRS score of the research group were(3.24±0.82),(2.87±0.77),(2.71±0.54)and(1.99±0.32)points respectively,which was lower than that before treatment(4.19±0.91)points.MRS score of the control group were(3.85±0.84),(3.10±0.81),(2.87±0.75)and(2.56±0.55)points respectively,which were lower than that before treatment(4.23±0.89)points.After 15 d of treatment,MRS score of the research group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 48 h,72 h,7 d and 15 d of treatment,serum S100βprotein and CRP levels of the two
作者
廖伟锋
罗凌云
宋宏中
饶俊平
LIAO Wei-feng;LUO Ling-yun;SONG Hong-zhong(Department of Internal Medicine-Neurology,Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital,Meizhou 514700,China)
出处
《中国现代药物应用》
2020年第9期10-13,共4页
Chinese Journal of Modern Drug Application
基金
2018年梅州市医药卫生科研立项课题(项目编号:2018-B-29)。
关键词
静脉溶栓
大株红景天
急性脑梗死
血清S100Β蛋白
C反应蛋白
Intravenous thrombolysis
Sofren injection
Acute cerebral infarction
Serum S100βprotein
C-reactive protein
