摘要
本文综述中药干预核转录因子-κB(NF-κB)信号通路中药治疗支气管哮喘的实验研究进展。NF-кB信号传导途径可以调控免疫/炎症细胞和气道结构细胞等,诱发支气管哮喘的发生及发展。近年来研究显示,多种中药复方、中药单味药及其提取物和中药单体可通过抑制NF-κB通路,减轻气道炎症和气道高反应,逆转气道重塑,在防治支气管哮喘方面有显著疗效。
This paper reviews the experiment research progress of Chinese medicine in the treatment of bronchial asthma via nuclear factor-κB(NF-κB) signaling pathway. NF-кB signaling pathway can regulate immune/inflammatory cells and airway structure cells, inducing the occurrence and development of bronchial asthma. In recent years, experimental studies have shown that a variety of traditional Chinese medicine compounds, traditional Chinese medicine single-drugs and their extracts and traditional Chinese medicine monomers can be passed inhibits NF-κB pathway, improves asthma symptoms, reduces airway inflammation and airway hyperresponsiveness, reverses airway remodeling, and achieves significant effects in preventing and treating bronchial asthma.
作者
武明云
虞坚尔
白莉
薛征
蒋沈华
徐万超
WU Mingyun;YU Jian′er;BAI Li;XUE Zheng;JIANG Shenhua;XU Wanchao(Institute of Pediatrics of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Shanghai Clinical College of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Pediatrics,Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《中国医药导报》
CAS
2020年第10期31-34,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81603662)
上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-1012]
上海市名老中医学术经验研究工作室建设项目(SHGZS-2017001)。
关键词
核转录因子信号通路
支气管哮喘
中药
综述
Nuclear transcription factor signaling pathway
Bronchial asthma
Chinese medicine
Review
