摘要
目的探讨单核细胞/高密度脂蛋白比值(MHR)与2型糖尿病(T2DM)合并下肢动脉硬化闭塞症(ASO)的相关性。方法选取2017年2月至2019年1月我院收治的340例T2DM患者作为研究对象,根据MHR四分位数将患者分成4组:A组(n=85):MHR<0.61×10^9;B组(n=85):MHR为(0.61~0.90)×10^9;C组(n=85):MHR为(0.91~1.17)×10^9;D组(n=85):MHR>1.17×10^9。单因素分析4组患者基线资料,对差异有统计学意义的单因素行Logistic回归分析,分析MHR与ASO相关性,探讨ASO独立危险因素并建立其预测模型。应用ROC曲线评价MHR对ASO的诊断效能。结果A组、B组、C组及D组患者ASO发生率分别为21.18%、24.70%、47.06%及56.47%,4组ASO发生率差异有统计学意义(P<0.001)。4组患者在体质指数、MHR、病程、单核细胞、空腹血糖、糖化血红蛋白(Hb A1c)、血清肌酐、血尿素氮、踝肱指数(ABI)、同型半胱氨酸(Hcy)、血尿酸(SUA)、空腹胰岛素、载脂蛋白A1、载脂蛋白B、稳态模型胰岛素抵抗指数(HOMA-IR)、甘油三酯、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇(LDLC)等指标差异有统计学意义(P<0.05)。Logistic回归分析表明,MHR、Hcy、HOMA-IR、LDLC、HbA1c和SUA是ASO发生的独立危险因素(P<0.05)。Pearson相关分析显示,MHR与ABI呈负相关关系(r=-0.742,P<0.001)。ROC曲线显示,MHR诊断ASO的临界值为0.91×10^9,灵敏度为79.53%,特异度为81.22%,曲线下面积为0.815。结论MHR是T2DM患者合并ASO发生的独立危险因素,其与ASO呈正相关关系,对ASO预测、评估有一定的价值。
Aim To explore the correlation between monocyte to high density lipoprotein ratio(MHR)and type2 diabetes mellitus(T2DM)with arteriosclerosis obliterans(ASO)of lower extremity.Methods 340 T2DM patients admitted to our hospital from February 2017 to January 2019 were selected as research objects.According to the quartile of MHR,the patients were divided into four groups:group A(n=85):MHR<0.61×10^9;group B(n=85):MHR(0.61-0.90)×10^9;group C(n=85):MHR(0.91-1.17)×10^9;group D(n=85):MHR>1.17×10^9.The baseline data of patients were analyzed by single factor analysis,and Logistic regression analysis was carried out for the single factor with statistical significance,in order to analyze the correlation between MHR and ASO.The independent risk factors of ASO were discussed and the prediction model was established.ROC curve was used to evaluate the diagnostic efficiency of MHR to ASO.Results The incidence of ASO in group A,group B,group C and group D were 21.18%,24.70%,47.06% and 56.47% respectively.There was significant difference in the incidence of ASO among the four groups(P<0.001).The differences of body mass index,MHR,course of disease,monocyte,fasting blood glucose,glycosylated hemoglobin A1(HbA1c),serum creatinine,blood urea nitrogen,ankle brachial index(ABI),homocysteine(Hcy),serum uric acid(SUA),fasting insulin,apolipoprotein A1,apolipoprotein B,homeostasis model assessment index of insulin resistance(HOMA-IR),triglyceride,high density lipoprotein cholesterol and low density lipoprotein cholesterol(LDLC)were statistically significant among the four groups(P<0.05).Logistic regression analysis showed that MHR,Hcy,HOMA-IR,LDLC,HbA1c and SUA were independent risk factors for ASO(P<0.05).Pearson correlation analysis showed that there was a negative correlation between MHR and ABI(r=-0.742,P<0.001).ROC curve showed that the cut-off value of MHR for ASO diagnosis was 0.91×10^9,the sensitivity was 79.53%,the specificity was 81.22%,and the area under curve was 0.815.Conclusion MHR is an independent risk factor for the
作者
李志超
孟钰
段会然
李恩
LI Zhichao;MENG Yu;DUAN Huiran;LI En(Department of General Surgery,Second People's Hospital of Anyang,Anyang,Henan 455000,China)
出处
《中国动脉硬化杂志》
CAS
2020年第3期242-246,252,共6页
Chinese Journal of Arteriosclerosis
关键词
单核细胞/高密度脂蛋白比值
2型糖尿病
动脉硬化闭塞症
下肢
相关性分析
monocyte to high density lipoprotein ratio
type 2 diabetes mellitus
arteriosclerosis obliterans
lower extremity
correlation
