摘要
目的 探讨外周血单核细胞计数/高密度脂蛋白比值(monocyte to high-density lipoprotein cholesterol ratio,MHR)比值在预测老年高血压患者伴发动脉粥样硬化性病变中的意义。方法 对2019年10月—2020年11月该院收治的120例老年高血压伴发动脉粥样硬化性病变患者进行回顾性分析,收集患者的基本资料,并按照颈动脉内中膜厚度(intima-media thickness,IMT)将其分为对照组(48例,IMT<0.9 mm)和高血压伴发动脉粥样硬化组(72例,IMT≥0.9 mm)。比较两组基本资料和实验室指标的差异,评估MHR预测高血压伴动脉粥样硬化性病变的价值。结果 高血压伴发动脉粥样硬化组吸烟者比例、白细胞计数、中性粒细胞计数、单核细胞计数、低密度脂蛋白(LDL)水平、尿酸水平、MHR均明显高于对照组,差异有统计学意义(P<0.05),且多因素Logistic回归分析结果 显示,有吸烟史(OR=1.982)、尿酸水平升高(OR=1.005)、MHR升高(OR=1.513)是老年高血压患者发生颈动脉粥样斑块形成的危险因素。结论 MHR升高与老年高血压患者伴发动脉粥样硬化有密切关联,是老年高血压患者伴发颈动脉粥样斑块形成的预测因子之一,具有一定的临床价值。
Objective To investigate the significance of peripheral blood monocyte count/high-density lipoprotein cholesterol ratio(MHR) ratio in predicting atherosclerotic lesions in elderly hypertensive patients.Methods From October 2019 to November 2020,120 elderly patients with hypertension and atherosclerotic lesions admitted to the hospital were retrospectively analyzed,and the basic data of the patients were collected.And according to carotid intima-media thickness(IMT),they were divided into control group(48 cases,IMT<0.9 mm) and hypertension with atherosclerosis group(72 cases,IMT≥0.9 mm).The differences in basic data and laboratory parameters between the two groups were compared,and the value of MHR in predicting hypertension with atherosclerotic lesions was evaluated.Results The proportion of smokers,white blood cell count,neutrophil count,monocyte count,low density lipoprotein(LDL) level,uric acid level and MHR in the hypertension complicated with atherosclerosis group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05),and multivariate logistic regression analysis showed that smoking history(OR=1.982),elevated uric acid level(OR=1.005),and elevated MHR(OR=1.513) were associated with carotid atherosclerotic plaque formation in elderly hypertensive patients risk factors.Conclusion Elevated MHR is closely related to atherosclerosis in elderly hypertensive patients,and it is one of the predictors of carotid atherosclerosis in elderly hypertensive patients,which has certain clinical value.
作者
曾德星
张丽旻
ZENG Dexing;ZHANG Limin(Department of Cardiovascular Medicine,the Second Hospital of Longyan City,Longyan,Fujian Province,364100 China;Department of Gastroenterology,the Second Hospital of Longyan City,Longyan,Fujian Province,364100 China)
出处
《中外医疗》
2022年第15期20-23,28,共5页
China & Foreign Medical Treatment
