摘要
目的探讨低分子肝素钠联合地屈孕酮片治疗复发性流产的疗效。方法选取2016年6月至2018年3月本院收治的50例复发性流产患者作为研究对象,按照随机表法分为对照组和治疗组,每组25例。对照组在确诊妊娠后给予肌内注射黄体酮20 mg,每天2次,治疗10周后改口服黄体酮胶丸100 mg,每天2次,至妊娠12周;治疗组在确诊妊娠后给予皮下注射低分子肝素钠4 250 IU,每天1次,同时给予地屈孕酮片10 mg,每天3次,至妊娠12周。比较两组患者妊娠结局、妊娠并发症、不良反应情况。结果两组患者妊娠结局比较,治疗组总活产率(92.00%)明显高于对照组(68.00%)(X^2=4.500,P=0.034);两组患者妊娠期高血压、糖尿病等并发症发生率比较差异无统计学意义;两组患者不良反应发生率比较差异无统计学意义。结论低分子肝素钠联合地屈孕酮片治疗复发性流产,能有效提高孕妇分娩成活率,且不良反应较少,值得临床推广。
Objective To investigate the efficacy of low molecular weight heparin sodium combined with diazoprogesterone tablets in the treatment of recurrent abortion. Methods A total of 50 patients with recurrent abortion admitted to our hospital from June 2016 to March 2018 were selected as the study subjects and randomly divided into control group and treatment group, with 25 cases in each group. The control group was given intramuscular injection of progesterone 20 mg twice a day after diagnosis of pregnancy. After 10 weeks of treatment, the control group was given oral progesterone capsule 100 mg twice a day to 12 weeks of gestation. In the treatment group, subcutaneous injection of LMWH 4 250 IU was given once a day after the diagnosis of pregnancy, and dendroprogesterone tablets 10 mg was given three times a day to 12 weeks of gestation. Pregnancy outcomes, pregnancy complications and adverse reactions were compared between the two groups. Results The total live birth rate(92.00%) in the treatment group was significantly higher than that in the control group(68.00%)(X^2=4.500, P=0.034). There was no significant difference in the incidence of gestational hypertension, diabetes and other complications between the two groups. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Low molecular weight heparin sodium combined with diquprogesterone tablets can effectively improve the survival rate of pregnant women in the treatment of recurrent abortion, and the adverse reactions are less, which is worthy of clinical promotion.
作者
邱颖婷
周婧婧
Qiu Yingting;Zhou Jingjing(Pingxiang Maternal and Child Health Hospital,Pingxiang,Jiangxi,337000,China)
出处
《当代医学》
2020年第14期96-98,共3页
Contemporary Medicine
关键词
低分子肝素钠
地屈孕酮片
复发性流产
疗效
Low molecular weight heparin sodium
Dimetoprogesterone tablets
Recurrent abortion
Curative effect
