摘要
共轭亚油酸(CLA)是一种人和动物自身无法合成但又不可缺少的脂肪酸,它具有抗癌、抗肥胖、抗动脉粥样硬化、抗糖尿病等潜在生理功能,被广泛用作食品营养补充剂。由于天然CLA来源较少、化学合成副产物较多,而利用乳酸菌生物合成的CLA结构单一且转化效率高,是一种有前景的合成方法。目前微生物将亚油酸(LA)转化为CLA的机制主要有2种,即以瘤胃微生物为主的生物氢化合成和乳酸菌为代表的多酶系合成。现有研究表明,CLA具有调节肠道菌群的作用,并指出其潜在生理功能可能与其对肠道微生态的影响密切相关。文章总结了CLA生物合成和影响因素,分析了CLA的生物合成机制以及其对肠道菌群的调节作用,为进一步筛选出高产CLA菌株和CLA的产业化应用提供理论依据。
Conjugated linoleic acid(CLA) is a fatty acid that cannot be synthesized by humans and animals,but it has potential physiological functions such as anti-cancer,anti-obesity,anti-atherosclerosis,and anti-diabetes.It is widely used as food nutritional supplements.Since natural CLA have fewer sources and more by-products in chemical synthesis,the use of lactic acid bacteria to synthesize CLA with a single structure and high conversion efficiency is a promising synthetic method.At present,there are two main types of mechanism by which microorganisms convert linoleic acid(LA) into CLA,namely biohydrogenation represented by rumen microorganisms and multi-enzyme synthesis represented by lactic acid bacteria.Research shows that CLA has a role in regulating the gut microbiota,and pointed out that its potential physiological function may be closely related to its the impact of intestinal microecology.This article analyzes the biosynthesis of CLA by lactic acid bacteria,investigating the factors influencing its production and its regulating effect on intestinal flora,and provide theoretical basis for further screening high-yield CLA strains and industrial applications of CLA.
作者
余梦为
郦萍
付碧石
顾青
YU Mengwei;LI Ping;FU Bishi;GU Qing(School of Life Sciences,Yangtze University,Jingzhou 434025,China;Key Laboratory for Food Microbial Technology of Zhejiang Province,School of Food and Biological Engineering,Zhejiang Gongshang University,Hangzhou 310018,China)
出处
《食品科技》
CAS
北大核心
2020年第3期28-35,共8页
Food Science and Technology
基金
国家重点研发计划项目(2016YFD0400405)。
关键词
共轭亚油酸
乳酸菌
合成机制
肠道菌群
conjugated linoleic acid
lactic acid bacteria
synthesis mechanism
gut microbiota
