摘要
目的探讨红细胞分布宽度与血小板计数比值与急性缺血性脑卒中患者短期预后的相关性。方法本研究前瞻性纳入2015年-2017年郑州大学第一附属医院发病24 h内缺血性脑卒中住院患者。记录研究对象红细胞分布宽度及血小板计数水平并计算两者比值(red cell distribution width to platelet ratio,RPR)及临床信息。90 d预后以改良Rankin量表(modified Rankin Scale,mRS)评分为标准。结果共纳入1106例患者。卒中后90 d预后不良者187例(16.9%),预后良好者919例(83.1%),与预后良好组相比,预后不良组的年龄更高(P<0.001);高血压(P=0.015)、糖尿病(P=0.001)、房颤(P<0.001)、冠心病(P=0.041)、卒中史(P<0.001)比例更高,入院时美国国立卫生研究院卒中量表评分(P<0.001),白细胞计数(P<0.001)、红细胞分布宽度(P<0.001)、RPR水平(P=0.034)均较高,且高水平RPR是90 d预后不良的预测因子[比值比(odds ratio,OR)1.09,95%可信区间(confidence interval,CI)1.03~1.16,P=0.005]。结论高水平RPR是急性缺血性脑卒中90 d预后不良的预测因子。
Objective To investigate the correlation between red cell distribution width to platelet ratio and short-term prognosis in acute ischemic stroke.Methods The patients with ischemic stroke admitted in the First Affiliated Hospital of Zhengzhou University during the initial 24 hours after the onset of disease between 2015-2017 were recruited prospectively.Red cell distribution width(RDW),platelet and clinical characteristics were recorded.Functional outcome at 90 days after ischemic stroke was evaluated by the modified Rankin Scale(mRS).Results Totally 1106 patients were included.Patients with poor functional outcome were older(P<0.001=and had more frequent histories of hypertension(P=0.015),diabetes(P=0.001),atrial fibrillation(P<0.001=,coronary heart disease(P=0.041),stroke(P<0.001=and higher National Institutes of Health Stroke Scale(NIHSS)(P<0.001=,white blood cell count(P<0.001=,RDW(P<0.001=and RDW to platelet ratio(RPR)(P=0.034).Higher RPR levels were associated with poor functional outcome at 90 days after ischemic stroke[(odds ratio,OR)1.09,(confidence interval,CI)1.03~1.16,P=0.005].Conclusion Higher RPR levels were associated with poor short-term outcome after acute ischemic stroke.
作者
王春慧
李友凤
胡睿瑶
田梦柯
王蹦
王鑫
李玉生
吴军
孙石磊
许予明
宋波
WANG Chunhui;LI Youfeng;HU Ruiyao(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中风与神经疾病杂志》
CAS
2020年第4期337-340,共4页
Journal of Apoplexy and Nervous Diseases
基金
国家自然科学基金面上项目(81571158)。
