摘要
目的:探讨维生素D联合左西替利嗪治疗儿童慢性自发性荨麻疹(CSU)的临床疗效。方法:将90例CSU患儿随机分为观察组与对照组,各45例,对照组予左西替利嗪口服(2~6岁:5 m L/次,>6岁:10 m L/次,每日1次),观察组在对照组基础上予联合维生素D口服(2~5岁:400 IU/d,>6岁:800 IU/d)。4周为1个疗程,同时测定2组治疗前、后血清25-羟基维生素D[25-(OH)D]水平,比较其临床疗效、血清25-(OH)D水平变化、不良反应及6个月后的复发率。结果:观察组有效率(91.11%)明显高于对照组(48.89%),2组比较差异有统计学意义(P<0.01)。2组治疗前血清25-(OH)D水平比较差异无统计学意义(P>0.05),治疗后观察组血清25-(OH)D水平与治疗前比较均明显提高(P<0.01),与对照组比较均明显提高(P<0.01),差异有统计学意义。随访6个月,复发率观察组[7.31%(3/41)]明显低于对照组[36.36%(8/22)],2组比较差异有统计学意义(χ2=7.28,P<0.01)。结论 :维生素D联合左西替利嗪口服治疗儿童CSU具有显著的临床效果和安全性。儿童CSU的发病可能与维生素D不足有关。
Objective: To investigate the therapeutic efficacy of vitamin D in combination with levocetirizine in the treatment of chronic spontaneous urticaria(CSU) in children. Methods: Ninety children with CSU were randomly divided into observation group(n=45) and control group(n=45). In the control group, children with the ages 2 to 6 years old took levectirizine hydrochloride oral solution, 5 m L each time, once a day, while children with the ages over 6 years old took 10 m L each time, once a day. The observation group was given oral vitamin D, in addition to levectirizine in the same way as that described for the con-trol group. Children with the ages 2 to 5 years old took 400 IU vitamin D daily, and children with the ages 6 years and older took 800 IU daily. The course of treatment is 4 weeks. The levels of serum 25-(OH)D were measured before and after treatment in both groups at the same time. The changes of serum 25-(OH)D levels, adverse reaction and the recurrence rate after 6 months from observation group and control group were compared to evaluate the therapeutic efficacy of vitamin D in combination with levocetirizine. Results: The effective rate of the observation group(91.11%) was significantly higher than that of the control group(48.89%)(P<0.01). There was no significant difference in serum 25-(OH)D levels between the two groups before treatment(P>0.05). The level of serum 25-(OH)D in the observation group was significantly increased after treatment(P<0.01). The level of serum 25-(OH)D in the observation group after treatment was significantly higher than that in the control group after treatment(P<0.01). A 6 month follow-up showed that the recurrence rate in the observation group[7.31%(3/41)] was significantly lower than that in the control group[36.36%(8/22)]( χ~2=7.28,P<0.01). Conclusion: Vitamin D in combination with levocetirizine hydrochloride oral solution has significant clinical efficacy and is safe in the treatment of CSU in children. CSU may be associated with vitamin D deficiency in children.
作者
汪浩
胡国华
刘宏亮
WANG Hao;HU Guo-hua;LIU Hong-liang(Department of Surgery,Medical College of Jinhua Vocational and Technical College,Jinhua 321000,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2020年第3期170-173,共4页
Journal of Clinical Dermatology
