摘要
背景:Wnt/β-catenin信号通路在骨关节炎的发展中起着重要的作用。目的:基于Wnt/β-catenin信号通路,对骨关节炎的研究进展做一综述。方法:查阅PubMed、中国知网和万方数据库,以“catenin;wnt;osteoarthritis;arthritis;degenerative;arthritides;deformans;pathway;wnt signaling;signaling pathway;wnt signaling pathways;wnt beta catenin signaling pathway;canonical wnt pathway;canonical wnt;骨关节炎”为检索词,分别组合检索,查找Wnt/β-catenin信号通路治疗骨关节炎的文献,最终纳入74篇文献进行分析。结果与结论:基于Wnt/β-catenin信号通路治疗骨关节炎,主要途径有天然的拮抗剂、小分子抑制剂、激动剂、中草药和药物重新定位等方面。药物作用途径通过激活或者抑制Wnt/β-catenin信号通路,对软骨起到保护作用。通过Wnt/β-catenin信号通路治疗骨关节炎,目前处于实验性研究阶段,但具有较好应用前景。如何精准调控通路,更好的转化应用,有望成为未来研究的热点。
BACKGROUND:Wnt/β-catenin signaling pathway plays a vital role in the development of osteoarthritis.OBJECTIVE:To review the recent progress of treating osteoarthritis based on the Wnt/β-catenin signaling pathway.METHODS:An electronical literature retrieval of PubMed,CNKI and WanFang databases was performed to search the literatures concerning the Wnt/β-catenin pathway in the treatment of osteoarthritis.The keywords were“catenin;wnt;osteoarthritis;arthritis;degenerative;arthritides;deformans;pathway;wnt signaling;signaling pathway;wnt signaling pathways;wnt beta catenin signaling pathway;canonical wnt pathway;canonical wnt”in English and Chinese,respectively.Finally,74 articles were included in result analysis.RESULTS AND CONCLUSION:The potential treatments of osteoarthritis based on the Wnt/β-Catenin signal pathway include natural antagonists,small molecule inhibitors,agonists,traditional Chinese medicine and drug reposition.These drug pathways provide chondroprotective effect via activating or inhibiting the Wnt/β-catenin signaling pathway.The treatment of osteoarthritis based on the Wnt/β-catenin signaling pathway is currently in the laboratory stage,but it has a great application prospect.How to accurately regulate the pathway and better transfer the research results into the application will become a hotspot in the future.
作者
贝涛
刘军廷
黄秋霖
苏伟
赵劲民
Bei Tao;Liu Junting;Huang Qiulin;Su Wei;Zhao Jinmin(Department of Traumatic Orthopaedics and Hand Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第29期4724-4730,共7页
Chinese Journal of Tissue Engineering Research
基金
广西科技基地和人才专项(桂科 AD17129012),项目负责人:赵劲民
广西大学生创新创业训练计划项目(201910598010),项目负责人:黄秋.
