摘要
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的2019冠状病毒病(COVID-19)是乙类传染病。随着COVID-19疫情蔓延,生物样本库样本保藏的生物安全风险增加,其生物安全防护显得越来越重要。根据国家有关规定和中华医学会相关指南,本文基于SARS-CoV-2病原学和COVID-19流行病学资料,提出了生物样本采集、转运、处理、保藏、检测、检测后处置、突发事件等过程中个人和生物样本保藏场所的生物安全防护原则及若干建议。强调依据有无病毒载量信息、传染力大小、标本类型(可能接触传播、气溶胶传播、粪口途径传播)对样本进行严格的生物安全风险评估,以指导疫情期间生物样本保藏、确保生物样本库生物安全。
Coronavirus disease 2019(COVID-19)is a grade B infectious disease caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).In pace with the spreading of the disease,biosafety risk of the biological specimen preservation in biobanks has been significantly increased and biosafety protection during biological specimen preservation become increasingly important.According to the related national rules and the corresponding guidelines of Chinese Medical Association,this paper introduced the etiology about SARS-CoV-2,epidemiology about COVID-19,and the biosafety protection principles of individuals and biological specimen storage places in the process of personal protection,protection of collection,transport,handling,preservation,detection,post-detection disposal and emergencies of biological specimen.Emphasized to carry out a strict biosafety-risk assessment on biological specimen basing on virus load information,infectivity,and sample type(possible contact transmission,aerosol transmission,and fecal oral transmission).
作者
张小燕
孙伟
尚世强
毛建华
傅君芬
舒强
江克文
ZHANG Xiaoyan;SUN Wei;SHANG Shiqiang;MAO Jianhua;FU Junfen;SHU Qiang;JIANG Kewen(BioBank of Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310051,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2020年第2期170-177,共8页
Journal of Zhejiang University(Medical Sciences)
基金
浙江大学新型冠状病毒(2019-nCoV)肺炎应急科研专项
国家自然科学基金(81871012)。
