摘要
目的探讨来曲唑和克罗米芬对多囊卵巢综合征(PCOS)患者的促排卵效果比较。方法将2016年1月-2018年1月治疗的120例PCOS患者随机分为两组,对照组采用克罗米芬,观察组采用来曲唑,比较两组患者的卵泡大小及个数、内膜厚度、排卵率、妊娠率、多胎率、流产率、宫外孕率。结果观察组成熟卵泡数明显少于对照组、子宫内膜厚度明显厚于对照组(P<0.05),成熟卵泡大小与对照组无明显差异(P>0.05),而两组在卵泡成熟所需天数上无明显差异(P>0.05);观察组妊娠率明显高于对照组(P<0.05),两组在排卵率、多胎率、流产率、宫外孕率上无明显差异(P>0.05)。结论来曲唑对PCOS患者的促排卵效果更佳,能有效促进卵泡成熟和排出,提高妊娠率。
Objective To compare the effects of letrozole and clomiphene on ovulation induction in patients with polycystic ovary syndrome. Methods 120 PCOS patients treated in the reproductive center of our hospital from January 2016 to January 2018 were randomly divided into two groups. The control group was treated with clomiphene, and the observation group with letrozole.The size and number of follicles, intimal thickness, ovulation rate, pregnancy rate, multiple pregnancy rate, abortion rate, and ectopic pregnancy rate were compared between the two groups.Results The number of mature follicles in the observation group was significantly less than that in the control group, and endometrial thickness was significantly thicker than that in the control group(P<0.05). There was no significant difference in the size of mature follicles between the two groups(P>0.05), and there was no significant difference in the number of days required for follicular maturation between the two groups(P>0.05). Pregnancy rate in the observation group was significantly higher than that in the control group(P<0.05), and there was no significant difference between the two groups in ovulation rate, multiple pregnancy rate, abortion rate, and ectopic pregnancy rate(P>0.05). Conclusions Letrozole has better effect on ovulation promotion in PCOS patients, can effectively promote follicular maturation and expulsion, and improve pregnancy rate.
作者
张喆
ZHANG Zhe(Liaoning Research Institute of Family Planning,Shenyang 110031,China)
出处
《航空航天医学杂志》
2020年第1期23-25,共3页
Journal of Aerospace medicine
