摘要
慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是耳鼻咽喉科常见疾病,是一种鼻腔鼻窦黏膜的慢性炎性疾病.虽然通过手术的方式可以治疗并改善患者的临床表现,但是仍有部分患者术后复发.关于CRSwNP的确切发病机制目前仍不清楚,其中B淋巴细胞及其所产生的抗体在CRSwNP的发病中有着重要作用,深入研究鼻息肉组织中B淋巴细胞及其抗体的产生有助于进一步了解CRSwNP的发病机制,进而帮助我们更有效的控制疾病症状和复发.本文就B淋巴细胞抗体产生的机制及其与CRSwNP的关系做一综述.
Chronic rhinosinusitis with nasal polyps(CRSwNP)is a common disease in Otorhinolaryngology,characterized by chronic inflammatory disorder.Endoscopic sinus surgery can result in a prolonged improvement in quality of life.However,there exists a high recurrence rate.The pathogenesis of CRSwNP is still unclear,of which B cell and its secreted antibody play a vital role.To explore B cells and antibodies within nasal polyps can help us control the symptom and the recurrence more effectively.In this review,we summarize how B cell produces antibody and correlates to CRSwNP.
作者
杜崑
陈彦
王向东
张罗
Du Kun;Chen Yan;Wang Xiangdong;Zhang Luo(Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Department of Immunology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Beijing Institute of Otolaryngology,Beijing Key laboratory of Nasal Diseases,Beijing 100005,China)
出处
《国际耳鼻咽喉头颈外科杂志》
2020年第2期90-95,共6页
International Journal of Otolaryngology-Head and Neck Surgery
基金
国家自然科学基金(81570894)
北京市自然科学基金(7172054)
北京市科技新星交叉学科合作项目(xxjc201712)。
关键词
B淋巴细胞
抗体
鼻窦炎
鼻息肉
Antibodies
B-Lymphocytes
Sinusitis
Nasal Polyps
