摘要
背景:目前科研、临床常用软骨功能成像序列有DWI、DTI、T1-mapping、T2-mapping、T2*-mapping等,其中T2-mapping常用于软骨定量分析中,然而因其扫描时间过长、受检者体验差导致常规开展该技术明显受限。目的:应用序列优化的磁共振T2-mapping定量成像技术评价慢性外侧踝关节不稳患者的距骨软骨损伤程度。方法:纳入于内蒙古医科大学第二附属医院就诊的53例慢性外侧踝关节不稳患者(病例组),同时纳入46例非慢性外侧踝关节不稳患者作为对照,均行磁共振常规扫描和优化的T2-mapping定量成像扫描,将距骨软骨分为内侧前、中、后部及外侧前、中、后部共计6个分区,每个分区取1个T2值,内、外侧分区共计6个T2值。试验获得内蒙古医科大学伦理委员会审核批准。结果与结论:病例组的内侧前部、内侧中部、内侧后部软骨区域的平均T2值均高于对照组(P<0.05),外侧区前、中、后部软骨区域的平均T2值与对照组比较差异无显著性意义(P>0.05)。结果表明,慢性外侧踝关节不稳患者的距骨软骨损伤主要发生于距骨内侧,磁共振T2-mapping成像技术能够定量测定软骨损伤程度,优化后的T2-mapping功能成像常规扫描成为可能。
BACKGROUND:At present,DWI,DTI,T1-mapping,T2-mapping,and T2*-mapping are commonly used in cartilage functional imaging sequences in both scientific research and clinic.T2-mapping is often used for the quantitative analysis of cartilage,but it was obviously limited due to the long scanning time and poor experience of the patient.OBJECTIVE:To quantitatively evaluate the talar cartilage injury degree of chronic lateral ankle instability patients by sequence optimized T2-mapping quantitative imaging technique.METHODS:Totally 53 cases of chronic ankle instability(case group)and 46 healthy subjects(control group)were from the Second Affiliated Hospital of Inner Mongolia Medical University.They underwent conventional Magnetic Resonance Imaging and optimal T2-mapping quantitative imaging scanning.The total talar cartilage was divided into six compartments:internal anterior,internal medial,internal posterior,lateral anterior,lateral center and lateral posterior.Six T2 values were totally taken as each partition had one T2 value.The experiment was approved by the Ethics Committee of Inner Mongolia Medical University.RESULTS AND CONCLUSION:The T2 values of internal anterior,internal medial,internal posterior areas of case group were higher than those of control group(P<0.05).The T2 values of lateral anterior,lateral center and lateral posterior areas had no significant difference between the two groups(P>0.05).The results showed that the talus cartilage injury mainly occurred in the internal talus in patients with chronic lateral ankle instability.The cartilage damage degree could be quantitatively evaluated by magnetic resonance T2-mapping imaging technique.It is possible that T2-mapping based on sequence optimization can be used in functional image routine scan.
作者
李伟
初占飞
于泽晨
于静红
贾岩波
王宗博
Li Wei;Chu Zhanfei;Yu Zechen;Yu Jinghong;Jia Yanbo;Wang Zongbo(Department of Imaging,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China;Siemens Healthineers Co.,Ltd.,Shanghai 201318,China;Department of Sports Medical Surgery,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第27期4333-4337,共5页
Chinese Journal of Tissue Engineering Research
基金
内蒙古自治区自然科学基金(2018MS08024),项目负责人:李伟
内蒙古自治区科技计划项目(2019GG053),项目负责人:李伟。
