摘要
以水解胶原蛋白、棕榈酰寡肽组成的肽类组合物-时光肽(Rejutime PTC)为研究对象,通过多种方法对其抵抗皮肤衰老的功效进行研究。结果显示,针对成纤维细胞(HDF-a)衰老模型,质量分数为0.125%~0.5%的PTC显著促进细胞增殖,并上调Ⅰ型胶原蛋白(COLⅠ)、Ⅲ型胶原蛋白(COL Ⅲ)和纤连蛋白的合成及分泌;针对角质形成细胞(NHEK)衰老模型,0.063%和0.25%的PTC处理细胞24~72 h可显著促进细胞增殖;对于真-表皮连接区(DEJ)的4种组成蛋白即层粘连蛋白-5、整合素β1、Ⅶ型胶原蛋白(COL Ⅶ)和Ⅳ型胶原蛋白(COL Ⅳ),PTC质量分数为0.063%~1%能促进其合成及分泌。PTC作为一种新型化妆品添加剂,针对皮肤表皮层、DEJ、真皮层发挥延缓皮肤衰老的作用。
The anti-aging effect of Rejutime PTC, a peptide composition composed of hydrolyzed collagen and palmitoyl oligopeptide, was evaluated through different methods. The results show that PTC with a mass fraction of 0.125% to 0.5% could significantly promote cell proliferation and up-regulate the synthesis and secretion of type Ⅰ, type Ⅲ collagens and fibronectin after 24 to 72 h treatment on the aging model of fibroblasts(HDF-a). On the NHEK keratinocytes aging model, 0.063% and 0.25% of PTC also significantly promote cell proliferation after treatment for 24 to 72 h. For the four constituent proteins of the dermal epidermal junction(DEJ), namely laminin-5, integrin β1, type Ⅶ collagen and type IV collagen, PTC increase their synthesis and secretion at concentrations from 0.063% to 1%. PTC, as a new cosmetic additive, can play a role in delaying skin aging for skin epidermis, DEJ and dermis.
作者
周春霞
周利丹
卢伊娜
ZHOU Chun-xia;ZHOU Li-dan;LU Yi-na(Shanghai JAKA Biotech Co.,Ltd.,Shanghai 200241,China)
出处
《日用化学工业》
CAS
CSCD
北大核心
2020年第4期263-268,共6页
China Surfactant Detergent & Cosmetics
