摘要
目的探讨转移因子胶囊和草分枝杆菌F.U.36注射液联合治疗女性复发性生殖器疱疹(RGH)的临床效果。方法选择2015年1月至2017年10月陕西省地方病防治研究所收治的248例女性RGH患者为研究对象,根究治疗方法分为观察组和对照组,每组124例。对照组患者给予草分枝杆菌F.U.36注射液治疗,观察组患者给予转移因子胶囊和草分枝杆菌F.U.36注射液联合治疗。分别于治疗前后检测2组患者外周血CD3+、CD4+、CD4+/CD8+水平及血清白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、单核细胞趋化蛋白1(MCP-1)水平,采用健康调查简表(SF-36)评价患者生活质量,采用视觉模拟评分法(VAS)评估患者自觉疼痛情况;于治疗后6个月评估2组患者临床疗效,并记录RGH复发及不良反应情况。结果2组患者治疗前CD3+、CD4+、CD4+/CD8+水平比较差异无统计学意义(P>0.05);2组患者治疗后CD3+、CD4+、CD4+/CD8+水平显著高于治疗前(P<0.05);治疗后,观察组患者CD3+、CD4+、CD4+/CD8+水平显著高于对照组(P<0.05)。2组患者治疗前血清IL-8、IL-10、MCP-1水平比较差异无统计学意义(P>0.05);2组患者治疗后血清IL-8、IL-10、MCP-1水平显著低于治疗前(P<0.05);治疗后,观察组患者血清IL-8、IL-10、MCP-1水平显著低于对照组(P<0.05)。2组患者治疗前VAS评分、SF-36评分比较差异无统计学意义(P>0.05);2组患者治疗后VAS评分显著低于治疗前,SF-36评分显著高于治疗前(P<0.05);治疗后,观察组患者VAS评分显著低于对照组,SF-36评分显著高于对照组(P<0.05)。观察组和对照组治疗总有效率分别为93.55%(116/124)、79.03%(98/124),观察组患者总有效率高于对照组(χ2=11.043,P<0.05);观察组和对照组患者复发率分别为7.76%(9/116)、27.55%(27/98),观察组患者复发率低于对照组(χ2=14.872,P<0.05)。观察组和对照组患者不良反应发生率分别为8.06%(10/124)、5.65%(7/124),2组患者不良反应发生率比较差异无统计学意�
Objective To investigate the clinical effect of transfer factor capsule combined with Mycobacterium phlei F.U.36 injection on female recurrent genital herpes(RGH).Methods A total of 248 women with RGH from January 2015 to October 2017 in Shaanxi Provincial Institute for Endemic Disease Control were selected as the research subjects.The patients were divided into observation group and control group,with 124 cases in each group.The patients in the control group were treated with Mycobacterium phlei F.U.36 injection,and the patients in the observation group were treated with transfer factor capsule and Mycobacterium phlei F.U.36 injection.Before and after treatment,the levels of CD3+,CD4+,CD4+/CD8+in peripheral blood and the levels of serum interleukin-8(IL-8),interleukin-10(IL-10),monocyte chemoattractant protein-1(MCP-1)of patients in the two groups were detected;the quality of life of the patients was evaluated by the 36-item short form health survey(SF-36);and the conscious pain was evaluated by visual analogue scales(VAS).The patients in the two groups were evaluated six months after treatment The recurrence and adverse reactions of RGH were recorded.The clinical effect of patients in the two groups were evaluated at six months after treatment,and the RGH recurrence and adverse reactions were recorded.Results There was no significant difference in the levels of CD3+,CD4+and CD4+/CD8+between the two groups before treatment(P>0.05).The levels of CD3+,CD4+and CD4+/CD8+after treatment were significantly higher than those before treatment in the two groups(P<0.05).The levels of CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group after treatment(P<0.05).There was no significant difference in the levels of serum IL-8,IL-10 and MCP-1 between the two groups before treatment(P>0.05).The levels of serum IL-8,IL-10 and MCP-1 after treatment were significantly lower than those before treatment in the two groups(P<0.05).The levels of serum IL-8,IL-10 and MCP-1 in the obser
作者
干娜
王耀斐
蔺兆星
刘乐
GAN Na;WANG Yaofei;LIN Zhaoxing;LIU Le(Shaanxi Provincial Institute for Endemic Disease Control,the Hospital of Shaanxi Provincial Institute for Dermatology and Venereology,Xi′an 710003,Shaanxi Province,China)
出处
《新乡医学院学报》
CAS
2020年第3期282-285,共4页
Journal of Xinxiang Medical University
