摘要
目的观察盐酸伐昔洛韦片联合膦甲酸钠治疗复发性生殖器疱疹(RGH)的临床疗效与安全性,分析联合用药对患者外周血免疫平衡的影响。方法选取攀枝花市中心医院在2014年1月至2017年1月收治的108例RGH女性患者,按照随机数字表法平均分为观察组和对照组(各54例),两组均给予盐酸伐昔洛韦片口服治疗,观察组另外联合膦甲酸钠氯化钠注射液静滴治疗。观察两组患者的临床疗效、止疱时间、结痂时间、血清炎症因子水平、外周血T细胞亚群水平、不良反应及复发率。结果观察组临床有效率为94.44%,高于对照组的79.63%(P<0.05);观察组止疱时间、结痂时间明显短于对照组(P<0.05);随访6个月,观察组复发率明显低于对照组(P<0.05);治疗后两组患者γ-干扰素(INF-γ)水平明显升高(P<0.05),白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)、IL-4水平明显下降(P<0.05),观察组INF-γ水平高于对照组(P<0.05),IL-2、TNF-α、IL-4水平低于对照组(P<0.05);治疗后两组患者CD3+T淋巴细胞(简称CD3细胞)、CD4+T淋巴细胞(简称CD4细胞)、CD4/CD8+T淋巴细胞(简称CD8细胞)水平明显升高(P<0.05),CD8细胞水平明显下降(P<0.05),观察组CD3细胞、CD4细胞、CD4/CD8细胞水平高于对照组(P<0.05),CD8细胞水平低于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P >0.05)。结论盐酸伐昔洛韦片联合膦甲酸钠治疗RGH患者疗效显著,复发率低,能够明显提高外周血免疫水平,值得临床推广。
Objective To observe the clinical efficacy and safety of valaciclovir hydrochloride combined with foscarnet sodium in the treatment of recurrent genital herpes(RGH),and to analyze the effect of combination therapy on peripheral blood immune balance.Methods 108 female patients with RGH were selected from Jan 2014 to Jan2017.The patients were divided into observation group and control group according to the random number table method.The two groups were given oral administration of Valaciclovir Hydrochloride Tablets,and the observation group was additionally treated with intravenous drip of Foscarnet Sodium and Sodium Chloride Injection.The clinical efficacy,the time of ceasing new blister,the time of incrustation,the serum levels of inflammatory factors,peripheral blood T lymphocyte subsets,adverse reactions and recurrence rate of the two groups were compared.Results The clinical effective rate of the observation group was 94.44%,higher than that of the control group(79.63%)(P<0.05).The blister time and scab time of the observation group were significantly shorter than those of the control group(P<0.05);after 6 months of follow-up,the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the level of INF-γin the two groups significantly increased,and the levels of IL-2,TNF-αand IL-4 decreased,with the level of INF-γin the observation group higher than that in the control group(P<0.05),and the levels of IL-2,TNF-αand IL-4 lower than those in the control group(P<0.05).After treatment,the levels of CD3+,CD4+,CD4+/CD8+ in the two groups significantly increased(P<0.05),and the level of CD8+significantly decreased(P<0.05).The levels of CD3+,CD4+,CD4+/CD8+ of the observation group were higher than those of the control group(P<0.05),and the level of CD8+ was lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P >0.05).Conclusion Valaciclovir hydrochloride combined
作者
杨万军
刘丽华
吴思
YANG Wanjun;LIU Lihua;WU Si(Dermatology & STD Department,Panzhihua Central Hospital of Sichuan Province,Panzhihua 617067,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2018年第10期1028-1031,共4页
Chinese Journal of Aids & STD
基金
国家973科技项目(2012CB722425)~~
关键词
伐昔洛韦
膦甲酸钠
复发性生殖器疱疹
免疫平衡
临床疗效
Valaciclovir
Foscarnet sodium
Recurrent genital herpes
Immune balance
Clinical efficacy
