摘要
目的研究新活素联合多巴胺对心肾综合征(CRS)患者肾动脉血流、尿中性粒细胞明胶酶相关脂质转运蛋白(NGAL)水平及运动耐量的影响。方法选取2016年5月至2018年4月该院收治的104例CRS患者作为研究对象,随机分为对照组和观察组,每组各52例。对照组患者采用多巴胺治疗,观察组患者采用新活素联合多巴胺治疗,比较两组患者治疗前后肾动脉血流参数:收缩期峰值血流速度(PSV)、肾动脉搏动指数(PI)、肾动脉阻力指数(RI);心功能指标:肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、B型脑钠肽(BNP);肾功能指标:NGAL、血清肌酐(SCr)、胱抑素-C(Cys-C);运动耐量:运动持续时间、运动量达最大时的心率及运动强度。结果与治疗前比较,两组患者治疗后PSV、运动持续时间、运动强度均升高,PI、RI、CK-MB、cTnT、BNP、NGAL、SCr、Cys-C水平均降低,差异均有统计学意义(P<0.05);与对照组治疗后比较,观察组患者PSV、运动持续时间、运动强度均升高,PI、RI、CK-MB、cTnT、BNP、NGAL、SCr、Cys-C水平均降低,差异均有统计学意义(P<0.05)。结论采用新活素联合多巴胺治疗CRS,能有效改善患者肾动脉血流、降低NGAL水平、改善患者运动耐量,从而缓解疾病进程。
Objective To study the effects of natriuretic peptide combined with dopamine on renal artery blood flow,urinary neutrophil gelatinase-related lipocalin(NGAL)level and exercise tolerance in patients with cardiorenal syndrome(CRS).Methods A total of 104 patients with CRS admitted to the hospital from May 2016 to April 2018 were divided into the control group and the observation group,with 52 cases in each group.The control group was treated with dopamine,while the observation group was treated with natriuretic peptide combined with dopamine.The changes of renal artery blood flow parameters,including peak systolic blood flow velocity(PSV),renal artery pulsation index(PI),and renal artery resistance index(RI),cardiac function indexes,including creatine kinase isoenzyme(CK-MB),troponin T(cTnT)and B-type brain natriuretic peptide(BNP),renal function indexes,including NGAL,serum creatinine(SCr),and Cystatin C(Cys-C),and exercise tolerance,duration of exercise,heart rate and intensity of exercise at maximum exercise were compared between the two groups before and after treatment.Results Compared with before treatment,PSV,exercise duration and exercise intensity increased,the levels of PI,RI,CK-MB,cTnT,BNP,NGAL,SCr and Cys-C decreased in the two groups after treatment,and the differences were statistically significant(P<0.05).Compared with the control group after treatment,the levels of PSV,exercise duration and exercise intensity in the observation group increased,while the levels of PI,RI,CK-MB,cTnT,BNP,NGAL,SCr and Cys-C decreased after treatment,and the differences were statistically significant(P<0.05).Conclusion Natriuretic peptide combined with dopamine can effectively improve renal artery blood flow,decrease urinary NGAL level and improve exercise tolerance in CRS patients,thus alleviating the disease process.
作者
黄炎焱
HUANG Yanyan(Department of Cardiology,Fengtai Hospital of Beijing,Beijing 100190,China)
出处
《检验医学与临床》
CAS
2020年第8期1040-1043,共4页
Laboratory Medicine and Clinic
关键词
新活素
多巴胺
心肾综合征
肾动脉血流
尿中性粒细胞明胶酶相关脂质转运蛋白
运动耐量
natriuretic peptide
dopamine
cardiorenal syndrome
renal artery blood flow
urinary neutrophil gelatinase-associated lipocalin
exercise tolerance
