摘要
[目的]探讨经外周静脉留置针输注强酸性药物(胺碘酮)与高渗药物复方氨基酸注射液(乐凡命)导致静脉炎的极限时间,为临床输注两类性质的药物,降低静脉炎发生提供组织形态学依据。[方法]选取72只健康日本大耳白兔为实验对象,按照随机数字表法分为胺碘酮组、乐凡命组、生理盐水组,各24只。经兔耳缘静脉穿刺给药后分别抽取3组2 h、3 h、4 h、5 h静脉血标本,运用酶联免疫分析法(ELISA)检测C-反应蛋白(CRP)浓度变化;适应性喂养4周后继续输注胺碘酮、乐凡命和生理盐水,再分别取2 h、3 h、4 h、5 h 4个时段穿刺部位近心端0.5 cm处、留置针尖端处、留置针尖端近心端0.5 cm处的活体标本制作病理切片,运用苏木精-伊红染色法(HE)观察组织形态变化。[结果]经重复测量方差分析,3组CRP浓度组间、时间、交互效应,差异均有统计学意义(P<0.05);胺碘酮组、乐凡命组输注药物3 h开始出现炎症反应;3组留置针尖端病理切片炎症反应程度比较差异有统计学意义(P<0.05)。[结论]经外周静脉留置针持续输注胺碘酮、乐凡命3 h为极限时间,实验对象出现轻微静脉炎反应,应制定科学、合理的静脉炎预防措施。
Objective:To explore the limit time of phlebitis caused by intravenous infusion of strong acid drugs amiodarone and hyperton-ic drugs(lefanming)through peripheral vein indwelling needle,so as to provide histomorphological basis for clinical infusion of two kinds of drugs and reduce the incidence of phlebitis.Methods:A total of 72 healthy Japanese white rabbits,were selected as experimental sub-jects.And they were divided into amiodarone group,lefanming group and normal saline group,according to random number table,with 24 rabbits in each group.Three groups of venous blood samples were taken from the ear margin of rabbits at 2 h,3 h,4 h and 5 h during con-tinuous intravenous injection.The concentration of c-reactive protein(CRP)was detected by enzyme linked immunosorbent assay(ELISA).After four weeks adaptive feeding,amiodarone,lefanming and physiological saline were injected once again.At 2 h,3 h,4 h and 5 h,pathological sections were made from living specimens of 0.5 cm from puncture sites to proximal end of venous,tip position,and 0.5 cm from tip position to proximal part.Then morphological changes were observed using hematoxylin eosin staining(HE).Results:Repeated measurement analysis of variance showed that there were statistically significant differences among three groups in concentration of CRP,time and interaction effect(P<0.05).Inflammatory reactions began to appear in the amiodarone group and lefanming after 3 hours of drug infusion group.There was statistically significant differences in inflammation reaction degree of pathological sections of the tip of the indwelling needle among three groups(P<0.05).Conclusion:The limit time of continuous infusion of amiodarone and lefanming through peripheral vein indwelling needle was 3 hours.And the experimental subjects had mild phlebitis.It was adviced that scientific and reasonable preventive measures should be formulated.
作者
闫鲜艳
郭锦丽
赵清丽
祁丽霞
杨婧
顾晓东
殷海洋
冯江峰
YAN Xianyan;GUO Jinli;ZHAO Qingli;QI Lixia;YANG Jing;GU Xiaodong;YIN Haiyang;FENG Jiangfeng(Shanxi Medical University,Shanxi 030001 China)
出处
《护理研究》
北大核心
2020年第8期1356-1360,共5页
Chinese Nursing Research
基金
山西省应用基础研究项目,编号:201701D121172。
关键词
静脉留置针
胺碘酮
乐凡命
生理盐水
静脉炎
极限时间
C-反应蛋白
炎症反应
intravenous indwelling needle
amiodarone
lefanming
normal saline
phlebitis
limit time
C-reactive protein
inflammatory res
