摘要
目的分析桂枝茯苓丸辅治慢性盆腔炎(chronic pelvic inflammatory disease,CPID)的临床疗效及对血液流变学、氧化应激和血清超敏-C反应蛋白(hs-CRP)、转化生长因子β1(TGF-β1)、巨噬细胞集落刺激因子(GM-CSF)、补体C3水平的影响。方法将2015年1月-2018年1月收治的120例CPID患者按随机数字表法设为观察组与对照组,每组60例。对照组给予奥硝唑,0.5 g/次,日2次口服,观察组在此基础辅以桂枝茯苓丸,6 g/次,日2次口服。比较两组临床疗效、中医症候量化评分、血液流变学、氧化应激及hs-CRP、TGF-β1、GM-CSF、补体C3水平;并统计不良反应发生率及随访复发率。结果观察组疗效等级、总有效率均显著优于对照组(P<0.05);治疗后两组中医症候量化评分、血液流变学及血清MDA、hs-CRP、TGF-β1、GM-CSF较治疗前均显著下降,且观察组低于对照组(P<0.05);SOD、GSH-PX、补体C3较治疗前显著上升,且观察组高于对照组(P<0.05);治疗期间两组均未见任意药物不良反应发生,但观察组复发率显著低于对照组(P<0.05)。结论较单一西药治疗CPID,桂枝茯苓丸辅治疗效更佳,并能降低复发风险,或与其对CPID患者血液流变学、氧化应激、机体免疫功能等改善更显著有关。
Objective To analyze the clinical curative effect of Guizhi Fuling Pills in the treatment of chronic pelvic inflammatory disease(CPID)and the influence on hemorheology,oxidative stress and levels of serum high-sensitivityC-reactive protein(hs-CRP),transforming growth factorβ1(TGF-β1),macrophage colony-stimulating factor(GM-CSF)andcomplement C3.Methods A total of 120 patients with CPID who were admitted to the hospital from January 2015 to January 2018 were divided into observation group and control group by the random number table method,with 60 cases in each group.The control group was treated with ornidazole,0.5 g orally,twice a day.On this basis,the observation group was treated with Guizhi Fuling Pills,6 g orally,twice a day.The clinical curative effect,TCM symptom scores,hemorheology,oxidative stress and levels of hs-CRP,TGF-β1,GM-CSF and complement C3 were compared between the two groups.The incidence of adverse reactions and the recurrence rate were statistically analyzed.Results The grade of curative effect and total effective rate of the observation group were significantly better than those of the control group(P<0.05).TCM symptom scores,blood rheology and levels of serum MDA,hs-CRP,TGF-β1 and GM-CSF were decreased after treatment,and thosewere lower in observation group than those of the control group(P<0.05).However,SOD,GSH-PX and complement C3 were significantly increased after treatment,and they were higher in observation groupthan those of the control group(P<0.05).No adverse drug reactions occurred during treatment,and the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).Conclusion Compared with single western medicine,the curative effect of Guizhi Fuling Pills assisted treatment is better.Besides,combined treatment can reduce the risk of recurrence,which is related to the improvement of hemorheology,oxidative stress and immune function in patients with CPID.
作者
王华斌
WANG Huabin(Gynecology Department,Eastern Branch of Sichuan People’s Hospital,Sichuan Academy of Medical Sciences,Chengdu 610000,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第2期214-217,共4页
Chinese Archives of Traditional Chinese Medicine
基金
四川省卫生与计划生育委员会科研项目(150216)。
关键词
桂枝茯苓丸
慢性盆腔炎
血液流变学
氧化应激
Guizhi Fuling Pills
chronic pelvic inflammatory disease
hemorheology
oxidative stress
