摘要
目的分析布地奈德联合孟鲁司特钠对哮喘患儿血清炎性因子和肺功能产生的影响。方法将我院在2016年2月至2017年3月接收的支气管哮喘患者共130例作为本次调查研究的对象,将所选取的调查对象随机分组,合理划分为对照组和研究组,对照组患者接受的是布地奈德气雾剂治疗方案,研究组患者在此基础上给予孟鲁司特钠片治疗,对比两组患者的治疗效果及血清细胞因子水平等指标。结果在接受不同的治疗方案之前,研究组和对照组患者在对比血清细胞因子水平的时候发现显现出的差异并不明显,不存在统计学意义(P>0.05)。当对照组患者采取了对应的治疗方案之后,TNF-α水平明显高于研究组的患者,IL-10水平明显低于研究组的患者,组间差异明显,可体现统计学意义(P<0.05)。在接受治疗之前,研究组患者和对照组患者的肺功能指标差异不明显,无法体现统计学意义(P>0.05)。在实施了对应的治疗方案之后,对照组患者的肺功能指标相较于研究组患者来说更低,差异明显且反映统计学意义(P<0.05)。研究组和对照组患者的治疗效果存在显著的差异,体现统计学意义(P<0.05)。结论在治疗哮喘时对患儿实施布地奈德联合孟鲁司特钠的治疗方案,能够稳步的提升哮喘患儿的肺功能,使其血清细胞因子水平得到改善,值得临床上推广并应用。
Objective To analyze the effects of budesonide combined with montelukast sodium on serum infl ammatory factors and pulmonary function in asthmatic children.Methods A total of 130 patients with bronchial asthma admitted in our hospital from February 2016 to March 2017 were selected as the subjects of this study.The selected subjects were randomly divided into two groups:control group and study group.The patients in the control group were treated with budesonide aerosol and the patients in the study group were treated with montelukast sodium tablet.The therapeutic effect and serum cytokine level were compared between the two groups.Results The comparison of serum cytokines levels in the Study Group and control group was not signifi cant and therefore could not be statistically signifi cant(P>0.05).When the control group of patients with the corresponding treatment,TNF level is signifi cantly higher than the study group of patients,IL-10 level is signifi cantly lower than the study group of patients,the difference between the two groups is signifi cant,can refl ect the statistical signifi cance(P<0.05).Before the treatment,the pulmonary function indexes of the patients in the study Group and the control group were not obvious and could not refl ect the statistical signifi cance(P>0.05).After receiving different treatment protocols,the lung function indexes of the control group were signifi cantly lower than those in the study group,and the difference was signifi cantly signifi cant(P<0.05).There was signifi cant difference in treatment effect between the study Group and the control group,and the difference was statistically signifi cant(P<0.05).Conclusion The treatment of budesonide combined with montelukast sodium in the treatment of asthma can steadily improve the lung function of asthmatic children and improve the level of serum cytokines,which is worthy to be popularized and applied in clinic.
作者
怀宝刚
HUAI Bao-gang(Pingyi County Traditional Chinese Medicine Hospital,Linyi 273300,China)
出处
《中国医药指南》
2020年第10期117-118,共2页
Guide of China Medicine
关键词
布地奈德
孟鲁司特钠
哮喘
血清炎性因子
肺功能
Budesonide
montelukast sodium
Asthma
Serum infl ammatory factors
Lung function
