摘要
目的:基于文献整理探讨中医药治疗系统性红斑狼疮(Systemic lupus erythematosus,SLE)的证候分类及用药规律演变。方法:检索中国知网(CNKI)、维普中文科技期刊数据库、中国学术期刊数据库中中医药治疗SLE的相关文献,时间限定为从数据库建立至2018年7月。对证型及药物进行分类并统计分析。结果:纳入文献725篇,总结归纳高频证型11个,出现频次最高的五个证型分别为热毒炽盛证、脾肾两(阳)虚证、阴虚内热(火旺)证、肝肾两(阴)虚证、气阴两虚证,累计频率62.11%。1965-2018年间,阴虚内热(火旺)证呈明显增长趋势;热毒炽盛证、脾肾两(阳)虚证及气阴两虚证在1965-2010年间呈增长趋势,在2011-2018年间呈下降趋势;肝郁气滞(脾虚)证在1965-2018年间呈下降趋势;其余证型均呈动态波动。涉及组方1522个,药物309味,使用15910次,总使用频率最高的5味药分别为生地黄、牡丹皮、茯苓、黄芪、甘草,总累计频率16.42%。使用频率最高药类为清热药和补虚药;生地黄、牡丹皮等清热药的使用频率趋势与热毒炽盛证保持一致,不同年份高频用药大致相似,用药频率存在较小差异。结论:SLE在内以阴阳亏虚为主,在外与热毒侵袭相关,属于本虚标实,其发展与生态环境、社会环境、药物使用等紧密相关,治当以清热凉血、活血祛瘀、益气养阴,并结合个人体质及环境变化辨证治疗。
Objective:To discuss the evolution of syndrome types and medication regularity of Chinese medicine for systemic lupus erythematosus(SLE)based on document sorting.Methods:Relevant literatures on Chinese medicine for SLE were retrieved from China National Knowledge Infrastructure(CNKI),VIP database,Wanfang Database.The time limit was from the establishment of database to July,2018.Classified and statistically analyzed syndrome types and medicine.Results:725 documents were enrolled.Summarized and generalized 11 high-frequency syndrome types,among which top five high-frequency syndrome types were heat-toxin hyperactivity syndrome,spleen-kidney(yang)deficiency syndrome,yin-deficiency and internal-heat(fire excess)syndrome,liver-kidney(yin)deficiency syndrome and qi-yin deficiency syndrome respectively,accounting for the total frequency of 62.11%.During 1965 and 2018,yin-deficiency and internalheat(fire excess)syndrome assumed an obvious growing trend.Heat-toxin exceeding syndrome,spleen-kidney(yang)deficiency syndrome and qi-yin deficiency syndrome assumed a growing trend during 1965 and 2010,while the syndrome types above assumed a downward trend during 2011 and 2018.During 1965 and 2018,liver depression and qi stagnation(spleen deficiency)syndromes assumed on obvious downward trend.Other syndromes assumed dynamic fluctuations.There were 1522 composed prescriptions,309 medicinals and 15910 times involved.The top five high-frequency medicinals were radix rehmanniae,cortex moutan,poria cocos,astragalus and glycyrrhiza respectively,accounting for the total frequency of16.42%.The top high-frequency medicines were heat-cleaning medicine and deficiency-supplying medicine.The frequency of such medicinals as radix rehmanniae and cortex moutan kept up with that of heat-toxin hyperactivity syndrome.Highfrequency medications were approximately similar in different years.There was slight difference being found in medication frequency.Conclusion:SLE is dominated by yin-yang deficiency internally and relevant with heat-toxin invas
作者
陈雷鸣
朱正阳
范永升
谢冠群
包洁
CHEN Leiming;ZHU Zhengyang;FAN Yongsheng;XIE Guanqun;BAO Jie
出处
《新中医》
CAS
2020年第5期20-25,共6页
New Chinese Medicine
基金
国家自然科学基金项目(81803980)
浙江省自然科学基金青年项目(LQ18H270004)
浙江中医药大学校级基金项目(2017ZR01)。
关键词
系统性红斑狼疮(SLE)
证型演变
用药规律
文献研究
Systemic lupus erythematosus(SLE)
Syndrome evolution
Medication regularity
Literature study
